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IL6 — PTK2

Text-mined interactions from Literome

Yamaki et al., Br J Pharmacol 1999 : Staurosporine induced increases in IL-6 production and expression of IL-6 mRNA were decreased by the PKC inhibitors, H-7 ( 2.7-27 microM ), Ro 31-8425 ( 1-10 microM ) and calphostin C ( 0.3-3 microM ) and by the phosphatidylinositol 3-kinase ( PI 3-kinase ) inhibitor LY294002 ( 30-100 microM ), but were further increased by the protein tyrosine kinase ( PTK ) inhibitor, genistein ( 12-37 microM )
Lin et al., Cancer Res 2002 (Multiple Myeloma) : Importantly, PTK787 also inhibits the increased MM cell proliferation and increased IL-6 and VEGF secretion in cultures of MM cells adherent to bone marrow stem cells
Zhou et al., Int J Hematol 2004 (Multiple Myeloma) : An association between CD45 and the Src-family protein tyrosine kinase , Lyn, was maintained in the presence of IL-6 ; the formation of the CD45/Lyn complex was impaired by vanadate
Schlaepfer et al., J Biol Chem 2007 : Inhibition of Src protein-tyrosine kinase activity or mutation of Src phosphorylation sites on FAK ( Tyr-861 or Tyr-925 ) did not affect TNFalpha stimulated IL-6 expression
Geng et al., J Immunol 1993 : In addition to cytokine mRNA levels, LPS induced IL-6 protein synthesis and IL-6 bioactivity were also reduced to baseline levels by the PTK inhibitors herbimycin A and genistein
Kong et al., Neurochem Int 1997 : This study examined the effects of two potent protein tyrosine kinase inhibitors, genistein and tyrphostin A25, on lipopolysaccharide (LPS) induced production of TNF alpha, IL-1 alpha, and IL-6 in mouse primary mixed glia, microglia- or astrocyte enriched cultures
Lazaar et al., J Immunol 1998 : These results delineate a potentially important CD40 mediated signal-transduction pathway in ASM, involving protein tyrosine kinase dependent calcium mobilization, NF-kappaB activation, and IL-6 production