Tai et al., Cancer Res 2003
(Multiple Myeloma) :
In addition, IGF-I triggers polymerization of F-actin, induces phosphorylation of p125(FAK) and paxillin, and enhances beta1 integrin interaction with these focal adhesion proteins
Chen et al., Carcinogenesis 1995
:
These findings suggest that an enhanced level of IGF-IR coupled with qualitative changes may be responsible for the activation of IGF-I dependent PTK on DES exposure