Annaert et al., Neuron 2001
:
PS1 deficiency results in the abnormal accumulation of TLN in a yet unidentified intracellular compartment
Esselens et al., J Cell Biol 2004
:
Importantly, the TLN accumulations are suppressed by adenoviral expression of wild-type, FAD linked and D257A mutant PS1 , indicating that this phenotype is independent from gamma-secretase activity