Gene interactions and pathways from curated databases and text-mining

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CDH2 — PSEN1

Text-mined interactions from Literome

Baki et al., Proc Natl Acad Sci U S A 2001 : Presenilin-1 binds cytoplasmic epithelial cadherin, inhibits cadherin/p120 association, and regulates stability and function of the cadherin/catenin adhesion complex
Uemura et al., Neurosci Lett 2006 : NMDA receptor stimulation also enhances PS1/gamma-secretase mediated cleavage of N-cadherin
Uemura et al., J Biol Chem 2007 (Alzheimer Disease) : Glycogen synthase kinase 3beta mediated phosphorylation of Presenilin 1 reduces its binding to N-cadherin , thereby down regulating its cell-surface expression