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PRKAA2 — ULK1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PRKAA2 — ULK1 (physical association, affinity chromatography technology) Behrends et al., Nature 2010
• IRef Intact Interaction: Complex of 29 proteins (physical association, anti tag coimmunoprecipitation) Behrends et al., Nature 2010

Text-mined interactions from Literome

Löffler et al., Autophagy 2011 : Ulk1 mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop ... This phosphorylation leads to the direct activation of Ulk1 by AMPK bypassing mTOR-inhibition
Shang et al., Autophagy 2011 : These studies show that both mTOR and AMPK directly regulate Ulk1 and coordinate the mammalian autophagy initiation
Khan et al., Molecular bioSystems 2012 : We propose that this ID nature facilitates AMPK mediated phosphorylation of ULK1 , which may provide a mechanism for ULK1 functions in response to nutrient deprivation
Sciarretta et al., Autophagy 2012 (Metabolic Syndrome X...) : Although MTORC1 and autophagy can be regulated through RHEB independent mechanisms, such as the AMPK dependent phosphorylation of RPTOR and ULK1 , RHEB appears to be critical in the regulation of MTORC1 and autophagy during ischemia in cardiomyocytes, and its dysregulation is relevant to human disease
Mack et al., Autophagy 2012 : AMPK dependent phosphorylation of ULK1 regulates ATG9 localization ... Moreover, we demonstrate that the immediate effect of AMPK dependent phosphorylation of ULK1 results in enhanced binding of the adaptor protein YWHAZ/14-3-3? ; and this binding alters ULK1 phosphorylation in vitro