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PLG — PRNP
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Bass et al., Biochem Soc Trans 2002
(Neurodegenerative Diseases) :
Recent observations demonstrate that certain forms of the
prion protein can
stimulate tissue plasminogen activator catalysed
plasminogen activation, which raises the possibility that these proteases may also have a role in the pathogenesis of the transmissible spongiform encephalopathies
Ellis et al., Biochemistry 2002
(Prion Diseases) :
Plasminogen activation is
stimulated by
prion protein and regulated in a copper dependent manner ... The
effect of recombinant
PrP , either containing copper ( holo-PrP ) or devoid of it ( apo-PrP ), on
plasminogen activation by both uPA and tPA was determined ...
PrP had no effect on
plasminogen activation by uPA
Epple et al., Journal of thrombosis and haemostasis : JTH 2004
:
We found that recombinant full-length
prion protein , PrP23-231, and PrP23-110 specifically
stimulate t-PA mediated
plasminogen activation ... Binding to
PrP23-110 is not
sufficient for stimulation of
plasmin generation ... Thus the lysine binding site of kringle 2 that is unique to t-PA appears to mediate the specific
stimulation of
plasminogen activation by the cellular
prion protein
Barnewitz et al., Neuroreport 2006
:
The cleavage of recombinant
PrP to a fragment corresponding to C1 can be
mediated by the protease
plasmin (Pln) in vitro, suggesting that plasmin might be responsible for the generation of the C1 fragment in vivo as well