Zhang et al., J Cereb Blood Flow Metab 2009
(Brain Ischemia) :
The results of our study indicate that the interaction between tPA and microglial LRP1 increases MMP-9 expression and activity resulting in the degradation of claudin-5 and development of cerebral edema
Kaur et al., J Cereb Blood Flow Metab 2011
(Brain Ischemia...) :
Both tPA and age independently increased claudin 5 and occludin phosphorylation during ischemia