Freeman et al., Am J Physiol 1998
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We conclude that ANG II regulates the Ca ( 2+ ) -dependent activation and translocation of cPLA2 through an AT1 receptor and that this event is targeted at the nucleus in VSMC
Muthalif et al., Proc Natl Acad Sci U S A 1998
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Norepinephrine ( NE ) and angiotensin II (Ang II) , by promoting extracellular Ca2+ influx, increase Ca2+/calmodulin dependent kinase II ( CaMKII ) activity, leading to activation of mitogen activated protein kinase ( MAPK ) and cytosolic phospholipase A2 (cPLA2) , resulting in release of arachidonic acid ( AA ) for prostacyclin synthesis in rabbit vascular smooth muscle cells