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LIF — PI3
Text-mined interactions from Literome
Thabard et al., Cytokine 2001
(MAP Kinase Signaling System...) :
In OPM-2 cells, IL-6, OSM and
LIF induce both signal transducers and activators of transcription ( STAT ), mitogen activated protein kinase ( MAPK ) and
phosphatidylinositol 3-kinase (PI 3-K) activation
Hiraoka et al., Kobe J Med Sci 2003
(Cardiomyopathies...) :
PI 3-kinase-Akt-p70 S6 kinase in hypertrophic
responses to
leukemia inhibitory factor in cardiac myocytes
Carino et al., Int J Cancer 2008
(Adenocarcinoma...) :
Leptin induction of cytokines/receptors generally involved JAK2 and MAPK activation, but
PI-3K phosphorylation was
required for leptin increase of
LIF , IL-1/IL-1R tI
Oh et al., J Biol Chem 1998
:
We found that
LIF induced the activation of
PI 3-kinase in cardiac myocytes ... Moreover, JAK1 binds to PI 3-kinase, and
LIF stimulation
increases the
PI 3-kinase activity in JAK1 immunoprecipitates