Zhang et al., BMC cancer 2008
(Adenocarcinoma...) :
SOCS3 possibly promoted degradation of PYK2 in a SOCS-box dependent manner and interfered with PYK2 related signaling events, such as cell migration
Lee et al., J Immunol 2010
:
During IL-15 mediated NK cell priming, SOCS2 interacted with phosphorylated proline-rich tyrosine kinase 2 (Pyk2) at tyrosine 402 ( p-Pyk2 ( Tyr402 ) ) and induced the proteasome mediated degradation of p-Pyk2 ( Tyr402 ) via ubiquitination
Zhang et al., Zhonghua Bing Li Xue Za Zhi 2012
(Adenocarcinoma...) :
SOCS3 possibly promoted degradation of Pyk2 in a SOCS-box dependent manner and interfered with cell migration