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LRP5 — PGP

Text-mined interactions from Literome

Broxterman et al., Leukemia 1999 (Acute Disease...) : With the purpose of further quantifying the potential contributions of Pgp mediated drug efflux and Mvp/LRP to drug resistance in AML we have investigated whether the transport function of Pgp and the expression of Mvp/LRP correlated with the accumulation of daunorubicin ( DNR ) and the in vitro resistance to DNR cytotoxicity ( LC50 by MTT assay ) in AML cells
Klunder et al., Hum Pathol 2003 (Neoplasm Recurrence, Local...) : Pgp or MRP-1 expression did not change significantly, but LRP expression increased significantly after chemotherapy
Damiani et al., Haematologica 1998 (Leukemia, Myeloid, Acute...) : A PGP overexpression was detected in 40/54 ( 74 % ) cases while an LRP overexpression was observed on 33/54 ( 61 % ) cases
Borg et al., Br J Haematol 1998 (Acute Disease...) : Our findings suggest that both LRP and Pgp are clinically relevant drug-resistance proteins and it may be necessary to modulate both LRP and Pgp functions in order to reverse the multidrug resistance phenotype in AML