Su et al., J Biol Chem 2009
(Carcinoma, Non-Small-Cell Lung...) :
Overexpression of BMP4 was able to induce premature senescence in lung cancer cells and this process required the participation of cyclin/cyclin dependent kinase (cdk) inhibitors p16(INK4a) and p21 ( WAF1/cip1 )
Chiu et al., Mol Cancer Res 2012
(Carcinoma, Hepatocellular...) :
We also establish that BMP4 can induce HCC cyclin dependent kinase (CDK)1 and cyclin B1 upregulation to accelerate cell-cycle progression