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OSM — VCAM1

Text-mined interactions from Literome

Ruprecht et al., J Neuropathol Exp Neurol 2001 (Multiple Sclerosis) : Functionally, OSM upregulated intercellular adhesion molecule-1, but did not induce vascular cell adhesion molecule-1 in HCEC
Yanai et al., In Vitro Cell Dev Biol Anim 2001 : As responsible molecules for stromal cell dependent hematopoiesis, expression of stem cell factor (SCF) ( a ligand of c-Kit ), vascular cell adhesion molecule ( VCAM-1 ) ( a ligand of VLA-4 ), and secretion of interleukin (IL)-6 were increased by OSM
Fritz et al., J Immunol 2006 : In this study, we investigated the role of OSM in regulation of VCAM-1 expression, and STAT6 tyrosine 641 phosphorylation in murine fibroblasts ... OSM induced VCAM-1 expression in C57BL/6 mouse lung fibroblasts ( MLF ) and NIH 3T3 fibroblasts at the protein and mRNA level in vitro ... STAT6 was not essential for OSM induced VCAM-1 or eotaxin-1 as assessed in STAT6 ( -/- ) MLF ... Induction of VCAM-1 by OSM was diminished by pharmacological inhibitors of PI3K ( LY294002 ) but not inhibitors of ERK1/2 ( PD98059 ) or p38 MAPK ( SB203580 )
Fearon et al., Arthritis Rheum 2006 (Arthritis, Rheumatoid...) : OSM enhanced cell surface expression of ICAM-1, but not VCAM-1 , on endothelial cells and RASFs
Modur et al., J Clin Invest 1997 (Aortic Aneurysm...) : Oncostatin M in vitro stimulated : ( a ) polymorphonuclear leukocyte ( PMN ) transmigration through confluent monolayers of primary human endothelial cells ; ( b ) biphasic PMN adhesion through rapid P-selectin expression, and delayed adhesion mediated by E-selectin synthesis ; ( c ) intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 accumulation ; and ( d ) the expression of PMN activators IL-6, epithelial neutrophil activating peptide-78, growth related cytokine alpha and growth related cytokine beta without concomitant IL-8 synthesis