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NGF — SPHK2

Text-mined interactions from Literome

Sobue et al., J Neurochem 2005 (Pheochromocytoma) : NGF induced an increase in SPHK enzyme activity and protein about double those in PC12 cells, and NGF induced SPHK1 mRNA was three times higher than in the control
Edsall et al., J Neurosci 1997 : Nerve growth factor (NGF) , a neurotrophic factor for pheochromocytoma PC12 cells, induced a biphasic increase in the activity of sphingosine kinase , the enzyme that catalyzes the formation of SPP
Rius et al., FEBS Lett 1997 (Pheochromocytoma) : Nerve growth factor (NGF) , basic fibroblast growth factor (bFGF), dibutyryl cAMP and forskolin, known differentiating agents for pheochromocytoma PC12 cells, induced sustained activation of sphingosine kinase , the enzyme responsible for the formation of the sphingolipid second messenger, sphingosine-1-phosphate, which mediates the mitogenic effects of certain growth factors ... Of the growth factors examined, NGF was the most potent activator of sphingosine kinase , inducing a 4-fold increase in Vmax