◀ Back to NGF
NGF — PLCG1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
PLCG1
→
NGF
(increases, NGF Activity)
Kraemer et al., Arterioscler Thromb Vasc Biol 1999*
Evidence: NGF induces prolonged activation of the Shc/MAP kinase pathway and phospholipase Cgamma compared with PDGF-BB.
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NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
NGF (dimer)/TRKA complex (NTRK1-NGF)
→
NGF (dimer)/TRKA/PLCgamma1/TRPV1 complex (NTRK1-NGF-PLCG1-TRPV1)
(modification, collaborate)
Chuang et al., Nature 2001*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
NGF (dimer)/TRKA complex (NTRK1-NGF)
→
PLCgamma1 (PLCG1)
(modification, collaborate)
Chuang et al., Nature 2001*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
NGF (dimer)/TRKA/PLCgamma1/TRPV1 complex (NTRK1-NGF-PLCG1-TRPV1)
→
PLCgamma1 (PLCG1)
(modification, collaborate)
Chuang et al., Nature 2001*
Evidence: mutant phenotype, assay, physical interaction
-
NCI Pathway Database Trk receptor signaling mediated by PI3K and PLC-gamma:
NGF (dimer)/TRKA/PLCgamma1/TRPV1 complex (NTRK1-NGF-PLCG1-TRPV1)
→
TRPV1 (TRPV1)
(modification, collaborate)
Chuang et al., Nature 2001*
Evidence: mutant phenotype, assay, physical interaction
-
Reactome Reaction:
NGF
→
PLCG1
(reaction)
Kouhara et al., Cell 1997
-
Reactome Reaction:
NGF
→
PLCG1
(indirect_complex)
Text-mined interactions from Literome
Rui et al., J Biol Chem 1999
:
Overexpression of either wild type or mutant SH2-Bbeta ( R555E ) did not alter tyrosyl phosphorylation of TrkA, Shc, or
phospholipase Cgamma in
response to NGF or
NGF induced activation of ERK1/2, suggesting that SH2-Bbeta may initiate a previously unknown pathway ( s ) that is essential for NGF induced neurite outgrowth
Kraemer et al., Arterioscler Thromb Vasc Biol 1999
:
NGF induces prolonged activation of the Shc/MAP kinase pathway and
phospholipase Cgamma compared with PDGF-BB
Zapf-Colby et al., Oncogene 1999
:
NGF , but not IGF-I,
stimulates tyrosine phosphorylation and activation of
PLC-gamma1 which can be inhibited in a dose dependent manner by phosphoinositide-specific phospholipase C ( PI-PLC ) inhibitor U73122 ( IC50=4 microM )
Choi et al., Mol Cells 2003
:
Association of Cbl with
PLC-gamma1 was
induced by epidermal growth factor (EGF) but not by
nerve growth factor (NGF)
Kamata et al., Arch Biochem Biophys 2005
:
Consistent with the suppression, NAC inhibited
NGF induced activation of TrkA, formation of receptor complexes comprising TrkA, Shc, Grb2, and Sos, and activation of
phospholipase Cgamma and phosphatidylinositol 3-kinase
Lo et al., J Biol Chem 2005
:
Moreover, overexpression of SAP in PC12 cells suppressed the
nerve growth factor dependent activation of extracellular signal regulated kinases 1/2 and
phospholipase Cgamma , in addition to inhibiting neurite outgrowth
Vetter et al., Proc Natl Acad Sci U S A 1991
(Adrenal Gland Neoplasms...) :
We now report that
NGF rapidly
induces tyrosine phosphorylation of
phospholipase C-gamma 1 ( PLC-gamma 1 ), and we present evidence that the responsible tyrosine kinase is either p140trk or a closely associated protein
Loeb et al., J Biol Chem 1994
:
These observations indicate that
phospholipase C-gamma 1 activation or other signaling pathways dependent on Tyr-785 autophosphorylation are selectively
required for regulation of peripherin expression by NGF, but not for many other functional
NGF responses
Ohmichi et al., Biochemistry 1993
:
AG879 also inhibited
NGF induced
PLC-gamma 1 phosphorylation, phosphatidylinositol-3 (PI3) kinase activation, the association of the tyrosine phosphorylated proteins pp100 and pp110 with the p85 subunit of PI-3 kinase, mitogen activated protein and raf-1 kinases, and c-fos induction
Karlsson et al., Cell Growth Differ 1998
:
NGF induced tyrosine phosphorylation of
phospholipase Cgamma , TrkA, and Shc was unaltered in the Shb overexpressing cells, whereas that of Shb was greatly enhanced in these cells compared with control PC12-neo cells
Meakin et al., J Neurochem 1998
:
Cells of the nnr5 line stably expressing TrkAS3 induce
NGF dependent SHC phosphorylation and phosphatidylinositol 3-kinase,
phospholipase Cgamma-1 , and prolonged mitogen activated protein kinase activation to absolute levels comparable to those in PC12 cells