Gene interactions and pathways from curated databases and text-mining

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NGF — PLCG1

Pathways - manually collected, often from reviews:

Text-mined interactions from Literome

Rui et al., J Biol Chem 1999 : Overexpression of either wild type or mutant SH2-Bbeta ( R555E ) did not alter tyrosyl phosphorylation of TrkA, Shc, or phospholipase Cgamma in response to NGF or NGF induced activation of ERK1/2, suggesting that SH2-Bbeta may initiate a previously unknown pathway ( s ) that is essential for NGF induced neurite outgrowth
Kraemer et al., Arterioscler Thromb Vasc Biol 1999 : NGF induces prolonged activation of the Shc/MAP kinase pathway and phospholipase Cgamma compared with PDGF-BB
Zapf-Colby et al., Oncogene 1999 : NGF , but not IGF-I, stimulates tyrosine phosphorylation and activation of PLC-gamma1 which can be inhibited in a dose dependent manner by phosphoinositide-specific phospholipase C ( PI-PLC ) inhibitor U73122 ( IC50=4 microM )
Choi et al., Mol Cells 2003 : Association of Cbl with PLC-gamma1 was induced by epidermal growth factor (EGF) but not by nerve growth factor (NGF)
Kamata et al., Arch Biochem Biophys 2005 : Consistent with the suppression, NAC inhibited NGF induced activation of TrkA, formation of receptor complexes comprising TrkA, Shc, Grb2, and Sos, and activation of phospholipase Cgamma and phosphatidylinositol 3-kinase
Lo et al., J Biol Chem 2005 : Moreover, overexpression of SAP in PC12 cells suppressed the nerve growth factor dependent activation of extracellular signal regulated kinases 1/2 and phospholipase Cgamma , in addition to inhibiting neurite outgrowth
Vetter et al., Proc Natl Acad Sci U S A 1991 (Adrenal Gland Neoplasms...) : We now report that NGF rapidly induces tyrosine phosphorylation of phospholipase C-gamma 1 ( PLC-gamma 1 ), and we present evidence that the responsible tyrosine kinase is either p140trk or a closely associated protein
Loeb et al., J Biol Chem 1994 : These observations indicate that phospholipase C-gamma 1 activation or other signaling pathways dependent on Tyr-785 autophosphorylation are selectively required for regulation of peripherin expression by NGF, but not for many other functional NGF responses
Ohmichi et al., Biochemistry 1993 : AG879 also inhibited NGF induced PLC-gamma 1 phosphorylation, phosphatidylinositol-3 (PI3) kinase activation, the association of the tyrosine phosphorylated proteins pp100 and pp110 with the p85 subunit of PI-3 kinase, mitogen activated protein and raf-1 kinases, and c-fos induction
Karlsson et al., Cell Growth Differ 1998 : NGF induced tyrosine phosphorylation of phospholipase Cgamma , TrkA, and Shc was unaltered in the Shb overexpressing cells, whereas that of Shb was greatly enhanced in these cells compared with control PC12-neo cells
Meakin et al., J Neurochem 1998 : Cells of the nnr5 line stably expressing TrkAS3 induce NGF dependent SHC phosphorylation and phosphatidylinositol 3-kinase, phospholipase Cgamma-1 , and prolonged mitogen activated protein kinase activation to absolute levels comparable to those in PC12 cells