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CBL — NGF

Text-mined interactions from Literome

Choi et al., Mol Cells 2003 : Association of Cbl with PLC-gamma1 was induced by epidermal growth factor (EGF) but not by nerve growth factor (NGF)
Scalabrino et al., Neurosci Lett 2006 (Nerve Degeneration...) : In both cases, Cbl deficiency increased SC and CSF NGF levels after the appearance of myelinolytic lesions in the SC white matter ( SCWM ) ( i.e. after the second post-TG month ), and these changes were normalised by Cbl treatment in the 4-month-totally gastrectomised ( TGX ) rats ... These findings demonstrate that : ( i ) Cbl deficiency increases SC and CSF NGF levels ; and ( ii ) endogenous NGF seems to play a noxious role in the progression of rat Cbl-D central neuropathy
Veber et al., J Neurosci Res 2008 (Vitamin B 12 Deficiency) : As we have previously demonstrated that Cbl deficiency increases tumor necrosis factor (TNF)-alpha and nerve growth factor (NGF) levels in the SC ( each of which is a known NF-kappaB activator ), we redetermined NF-kappaB levels in the SCs and livers of TGX rats treated with anti-TNF-alpha or anti-NGF antibodies and found that NF-kappaB levels normalized in both tissues after either treatment
Sproul et al., Cell Res 2009 : NGF deprivation also induced rapid loss of tyrosine phosphorylation ( and most likely, activation ) of c-Cbl
Takahashi et al., FEBS Lett 2011 : Taken together, our data demonstrate that c-Cbl can induce downregulation of NGF-TrkA complexes through ubiquitination and degradation of TrkA