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NFKB1 — RAC1

Pathways - manually collected, often from reviews:

• KEGG Pancreatic cancer: RAC1/RAC2/RAC3 → NFKB1/RELA (protein-protein, activation)

Text-mined interactions from Literome

Huttunen et al., J Biol Chem 1999 (Neuroblastoma) : In contrast, the activation of NF-kappaB is inhibited by dominant negative Ras but not Rac or Cdc42
Courilleau et al., J Biol Chem 2000 : To investigate the role of B-ind1 in Rac1 signaling, we have constructed several deletion mutants of B-ind1 and tested their ability to affect the activation of NF-kappaB by Rac1 ... Interestingly, the fragment encoding the median region of human B-ind1 acted as a dominant negative variant to block Rac1 mediated NF-kappaB activity
Deshpande et al., FASEB J 2000 : Expression of Rac1N17 blocked TNF induced activation of nuclear factor-kappa B (NF-kappaB) , increased activity of caspase-3, and markedly augmented endothelial cell susceptibility to TNF induced apoptosis
Cammarano et al., J Biol Chem 2001 : Here we show that although Dbl activation of NF kappa B requires Cdc42, Rac , and Rho, the different GTPases activate NF kappa B by different mechanisms
Sanlioglu et al., J Biol Chem 2001 : Expression of a dominant negative mutant of Rac1 ( N17Rac1 ) reduced Rac1 activation, ROS formation, NFkappaB activation, and TNFalpha secretion following LPS stimulation
Zhao et al., Biochem J 2002 : We also demonstrate that SP rapidly activates RhoA, Rac1 and Cdc42 and that co-expression of the dominant negative mutants of RhoA, Rac1 and Cdc42 in NK-1R cDNA transfected NCM460 cells significantly inhibits SP-induced NF-kappaB dependent gene expression
Tzima et al., EMBO J 2002 : Additionally, Rac1 mediates flow induced stimulation of nuclear factor kappaB (NF-kappaB) and the subsequent expression of intercellular cell adhesion molecule 1 ( ICAM-1 ), an adhesion receptor involved in the recruitment of leukocytes to atherosclerotic plaque
Chen et al., J Pharmacol Exp Ther 2003 : Ad.N17Rac1 did not inhibit TNF-alpha induced activation of nuclear factor-kappaB (NF-kappaB) binding activity or inhibitor of NF-kappaB-alpha degradation
Higuchi et al., J Biol Chem 2003 : Expression of a dominant negative mutant of ASK1 eliminated the RacV12 induced NF-kappaB activation and the biochemical and morphological hypertrophic responses, whereas expression of a dominant negative form of Rac1 attenuated phenylephrine induced activation of ASK1 and NF-kappaB and cardiac myocyte hypertrophy
Wroblewski et al., J Cell Sci 2003 (Neoplasm Invasiveness) : RhoA acted through activation of both NF-kappaB and AP-1, whereas Rac activated NF-kappaB but not AP-1
Chen et al., Am J Physiol Heart Circ Physiol 2004 : Expression of N17Rac1 inhibited TNF-alpha induced MCP-1 and NF-kappaB transcriptional activity
Grassl et al., Cell Microbiol 2003 (MAP Kinase Signaling System) : Using Clostridium difficile toxins that specifically inactivate small GTPases, and transfection of inhibitory proteins of the Rho-GTPases, we demonstrate that Rac1 , but not Cdc42 or Rho, is required for activation of NF-kappaB by invasin
Chen et al., Biochem Biophys Res Commun 2004 : These results indicate that fMLP stimulates three members of the Rho family of GTPases Rac1, Cdc42, and RhoA activity in monocytes, and that Rac1 and RhoA, but not Cdc42, is required for fMLP induced NF-kappaB activation
Reddig et al., J Biol Chem 2005 : Additionally, suppression of endogenous Nischarin protein with small interfering RNA in PC12 cells enhanced Rac1Q61L and Rac1Q61L-40C activation of NF-kappaB
Schmeck et al., Am J Physiol Lung Cell Mol Physiol 2006 : Pneumococci induced TLR- and Rac1 dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells ... In summary, these results suggest that S. pneumoniae activate human epithelial cells by TLR1/2 and a phosphatidylinositol 3-kinase- and Rac1 dependent NF-kappaB-recruitment to the IL-8 promoter
Sakoda et al., J Dent Res 2006 : Dominant negative Rac1 severely inhibited interleukin-1alpha induced NF-kappaB and AP-1 promoter activity
Bauer et al., Exp Cell Res 2007 (Melanoma...) : Rac1 stimulates NFkappaB , and we found that endogenous NFkappaB activity of FEMX-V cells was 2 % of that of FEMX-I cells ... Inhibition of Rac1 resulted in blocked NFkappaB activity
Bianchi et al., Neurobiol Aging 2010 (Encephalitis...) : We have reported that RAGE ligation by S100B in BV-2 microglia results in the upregulation of expression of the pro-inflammatory cyclo-oxygenase 2 (COX-2) via parallel Ras-Cdc42-Rac1 dependent activation of c-Jun NH ( 2 ) terminal protein kinase ( JNK ) and Ras-Rac1 dependent stimulation of NF-kappaB transcriptional activity
Venkatesan et al., J Mol Cell Cardiol 2010 : EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1 dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling ... We show for the first time that EMMPRIN stimulates the activation of NF-kappaB, AP-1, CREB, and ATF-2 in cardiomyocytes, and induces IL-18 expression via Rac1 dependent PI3K/Akt/IKK/NF-kappaB and MKK7/JNK/AP-1 signaling
Perona et al., Genes Dev 1997 : The human RhoA, CDC42, and Rac-1 proteins efficiently induce the transcriptional activity of nuclear factor kappaB (NF-kappaB) by a mechanism that involves phosphorylation of Ikappa Balpha and translocation of p50/p50 and p50/p65 dimers to the nucleus, but independent of the Ras GTPase and the Raf-1 kinase ... In contrast, activation of NF-kappaB by UV light was not affected by Rho, CDC42, or Rac-1 dominant negative mutants