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F2RL1 — MUC13

Text-mined interactions from Literome

Chokki et al., Am J Respir Cell Mol Biol 2004 : These results indicate that HAT enhances mucin gene expression through an AR-EGFR pathway, and PAR-2 is not sufficient for or does not directly cause HAT induced mucin gene expression
Jarry et al., Biochem Biophys Res Commun 2007 (Calcium Signaling) : PAR-2 activation increases human intestinal mucin secretion through EGFR transactivation ... The aim of this study was to examine the effect of PAR-2 activation on mucin secretion in the human colonic goblet cell line HT29-Cl.16E and the intracellular pathways involved ... Inhibitors of MAPK activation ( PD98059 ) and EGFR tyrosine kinase activity ( AG1478 ) abrogated PAR-2 induced ERK1/2 and EGFR tyrosine phosphorylation, respectively, and subsequent mucin secretion ... Our results show that the activation of PAR-2 expressed by human intestinal epithelial cells enhances mucin secretion, a component of the intestinal innate defence, via a pathway involving EGFR transactivation
Lin et al., Int J Biochem Cell Biol 2008 (Cell Transformation, Viral) : The results suggest that, since PAR-2 activation only weakly increases mucin secretion by human airway epithelial cells in vitro, PAR-2 probably is not a significant contributor to mucin hypersecretion in inflamed airways