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MSH2 — NOS2

Text-mined interactions from Literome

Galimberti et al., Biochem Biophys Res Commun 1999 : Northern blot analysis demonstrated that alpha-MSH [ 1-13 ] and alpha-MSH [ 11-13 ] inhibited accumulation of inducible nitric oxide synthase (iNOS) and TNFalpha mRNA was triggered by Abeta stimulation
Gupta et al., Kidney Int 2000 : In contrast, alpha-MSH ( 100 nmol/L ) had no effect on the induction of NOS2 promoter-luciferase genes harboring deletion or mutation of the C/EBP box ... These data indicate that alpha-MSH inhibits the induction of C/EBPbeta DNA binding activity and that this effect is a major mechanism by which alpha-MSH inhibits the transcription of the NOS2 gene
Caruso et al., Neuroendocrinology 2004 : alpha-MSH and HS024 ( 1 nmol/rat ) alone had no effect on iNOS and COX-2 expression
Colombo et al., Shock 2007 (Inflammation...) : Bleomycin induced expression of proinflammatory and profibrotic factors ( interleukin 6, tumor necrosis factor-alpha, transforming growth factor-beta1, and inducible nitric oxide synthase ) and chemokines ( chemokine [C-C motif] ligand 2 and chemokine [C-C motif] ligand 5 ) was likewise significantly reduced by NDP-alpha-MSH
Caruso et al., Endocrinology 2007 (Inflammation) : alpha-MSH ( 5 microm ) reduced the nitric oxide production and the expression of inducible nitric oxide synthase (iNOS) induced by bacterial lipopolysaccharide ( LPS, 1 microg/ml ) plus interferon-gamma ( IFN-gamma, 50 ng/ml ) in cultured astrocytes after 24 h. alpha-MSH also attenuated the stimulatory effect of LPS/IFN-gamma on prostaglandin E ( 2 ) release and cyclooxygenase-2 (COX-2) expression