Ichiyama et al., Brain Res 1999
(Brain Diseases...) :
The effects of alpha-MSH on NF-kappaB and IkappaBalpha were paralleled by pretreatment with alpha-MSH11-13
Ichiyama et al., J Neuroimmunol 1999
(Acute Disease...) :
Centrally administered alpha-MSH inhibited peripheral NF-kappaB activation and IkappaBalpha degradation even in mice with nonfunctional melanocortin 1 receptors (MC1R)
Zou et al., Shock 2003
(Reperfusion Injury) :
In addition, we found that combined use of alpha-MSH , a known inhibitor of IkappaBalpha tyrosine phosphorylation, with BAY 11-7085, an inhibitor of IkappaBalpha Ser 32,36 phosphorylation, abrogates gut MPO induction and tissue injury at early and late time points of reperfusion