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MMP8 — NM

Text-mined interactions from Literome

Lin et al., Am J Pathol 2008 (Inflammation...) : In contrast to wild-type mice, we found that i ) lipopolysaccharide (LPS) injected CXCR2 ( -/- ) corneas had impaired neutrophil infiltration and did not express either MMP-8 or MMP-9 ; ii ) neutrophil migration through the central cornea was impaired in Mmp8 ( -/- ), but not Mmp9 ( -/- ), mice ; iii ) neutrophil migration was inhibited in collagenase-resistant mice ; iv ) the chemotactic Pro-Gly-Pro (PGP) tripeptide that binds CXCR2 was decreased in CXCR2 ( -/- ) mice ; v ) PGP production was impaired in Mmp8 ( -/- ) corneas ; and vi ) neutralizing anti-PGP antibody did not inhibit neutrophil infiltration in Mmp8 ( -/- ) mice ... Together, these studies indicate that neutrophils contribute to the production of both MMP-8 and MMP-9 in LPS injected corneas and that MMP-8 regulates neutrophil migration through the dense collagenous ECM of the corneal stroma by generating chemotactic PGP during inflammation
Cox et al., Arthritis Rheum 2010 (Arthritis, Experimental...) : Our findings indicate that MMP-8 is not essential for neutrophil migration in arthritis and likely other autoimmune diseases