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MCL1 — PMAIP1

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Jin et al., Br J Cancer 2011*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Craxton et al., Cell Death Differ 2012*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Stankiewicz et al., Cell Death Differ 2009*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Boiani et al., J Biol Chem 2013*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Tang et al., Mol Pharmacol 2012*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Chen et al., Mol Cell 2005
• IRef Biogrid Interaction: PMAIP1 — MCL1 (physical association, affinity chromatography technology) Willis et al., Genes Dev 2005*
• IRef Biogrid Interaction: PMAIP1 — MCL1 (direct interaction, pull down) Warr et al., J Biol Chem 2011*
• IRef Corum Interaction: PMAIP1 — MCL1 (association, pull down) Certo et al., Cancer Cell 2006
• IRef Hprd Interaction: MCL1 — PMAIP1 (in vitro) Chen et al., Mol Cell 2005, Certo et al., Cancer Cell 2006
• IRef Intact Interaction: PMAIP1 — MCL1 (physical association, anti tag coimmunoprecipitation) Willis et al., Genes Dev 2005*
• IRef Intact Interaction: PMAIP1 — MCL1 (direct interaction, surface plasmon resonance) Smith et al., J Biol Chem 2011*
• IRef Intact Interaction: PMAIP1 — MCL1 (physical association, pull down) Smith et al., J Biol Chem 2011*
• IRef Intact Interaction: Complex of PMAIP1-MCL1-BCL2L11-BCL2L11 (association, anti bait coimmunoprecipitation) Aikawa et al., FEBS Lett 2010*
• IRef Intact Interaction: Complex of BAK1-PMAIP1-MCL1-BCL2L11 (association, anti bait coimmunoprecipitation) Zhang et al., Oncogene 2011*

Text-mined interactions from Literome

Willis et al., Genes Dev 2005 : Accordingly, the BH3-only protein Noxa could bind to Mcl-1, displace Bak, and promote Mcl-1 degradation, but Bak mediated cell death also required neutralization of Bcl-x ( L ) by other BH3-only proteins
Czabotar et al., Proc Natl Acad Sci U S A 2007 : Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels