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CNR2 — MAPK1

Text-mined interactions from Literome

Herrera et al., FEBS Lett 2005 (Leukemia) : p38 MAPK is involved in CB2 receptor induced apoptosis of human leukaemia cells ... Results show that stimulation of the CB2 receptor leads to p38 MAPK activation and that inhibition of this kinase attenuates CB2 receptor induced caspase activation and apoptosis ... These findings support a role for p38 MAPK in CB2 receptor induced apoptosis of human leukaemia cells
Gertsch et al., Communicative & integrative biology 2008 : In this addendum, the CB(2) receptor dependent effect of beta-caryophyllene on LPS triggered activation of the kinases Erk1/2 and JNK1/2 are further discussed with respect to the possibility that both CB(2) inverse agonists and agonists, independent of their G-protein signaling, may block LPS triggered activation of MAPKs, leading to inhibition of proinflammatory cytokine expression and attenuation of inflammation
Signorello et al., J Cell Biochem 2011 : The 2-AG effect on p38MAPK was not impaired by apyrase, indomethacin or RGDS peptide but it was significantly reduced by SR141716, specific inhibitor of type-1 cannabinoid receptor and unaffected by the specific inhibitor of type-2 cannabinoid receptor SR144528
Merighi et al., Br J Pharmacol 2012 (MAP Kinase Signaling System) : Stimulation of CB(2) receptors by JWH-015 activated JNK-1/2 and ERK-1/2 in quiescent murine microglial cells ... Furthermore, CB(2) receptor activation increased p-ERK-1/2 at 15 min in LPS stimulated microglia