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AGTR1 — MAPK1

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: MAPK1 → AGTR1 (increases, AGTR1 Activity, MAPK1 Activity)
  Evidence: The ERK pathway is the best characterized of the MAPK pathways. Binding of ANG II to AT1Rs activates ERK1/2 within 5 minutes, and in VSMCs ERK 1/2 activity is blocked by inhibition of PLC, suggesting its dependency on calcium (42).
• OpenBEL Selventa BEL large corpus: MAPK1 → AGTR1 (increases, AGTR1 Activity, MAPK1 Activity)
  Evidence: miR-155 transfected cells showed a significant reduction in angiotensin II-induced extracellular signal-related kinase 1/2 (ERK1/2) activation.
• WikiPathways Hypothesized Pathways in Pathogenesis of Cardiovascular Disease: Complex of ANGPT2-AGTR1 → Complex of MAPK3-MAPK8-MAPK1-MAPK14 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: MAPK1 — AGTR1 (physical association, affinity chromatography technology) Luttrell et al., Proc Natl Acad Sci U S A 2001
• IRef Hprd Interaction: Complex of 51 proteins (in vivo) Luttrell et al., Proc Natl Acad Sci U S A 2001
• IRef Hprd Interaction: Complex of 26 proteins (in vivo) Tohgo et al., J Biol Chem 2003
• IRef Innatedb Interaction: AGTR1 — MAPK1 (unknown, -) Luttrell et al., Proc Natl Acad Sci U S A 2001

Text-mined interactions from Literome

Luttrell et al., Proc Natl Acad Sci U S A 2001 : Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal regulated kinase 2 ( ERK2 ) following stimulation of angiotensin II type 1a receptors (AT1aR)
Touyz et al., J Hypertens 2001 (Hypertension) : Differential activation of extracellular signal regulated protein kinase 1/2 and p38 mitogen activated-protein kinase by AT1 receptors in vascular smooth muscle cells from Wistar-Kyoto rats and spontaneously hypertensive rats
Bobrovskaya et al., J Neurochem 2001 (MAP Kinase Signaling System) : Angiotensin II ( AII, 100 nM ) stimulation of bovine adrenal chromaffin cells ( BACCs ) produced angiotensin II receptor subtype 1 (AT1) mediated increases in extracellular regulated protein kinase 1/2 ( ERK1/2 ) and stress activated p38MAPK ( p38 kinase ) phosphorylation over a period of 10 min. ERK1/2 and p38 kinase phosphorylation preceded Ser31 phosphorylation on tyrosine hydroxylase (TOH)
Hines et al., Biochem Pharmacol 2003 : The failure of a protein kinase C inhibitor to block AT(1) receptor activation of p42/44(MAPK) further corroborated evidence that the receptor 's activation of p42/44(MAPK) is largely independent of the G ( q ) /PLC-beta/PKC pathway ... Taken together, the experimental evidence strongly suggests that the mechanism whereby the AT(1) receptor activates p42/44(MAPK) is fundamentally different from that for PLC-beta, even at the level of the receptor itself
Kumar et al., J Cardiovasc Pharmacol Ther 2003 (Disease Models, Animal...) : Our aim was to assess the effect of selective AT1 and AT2 receptor blockade with losartan and PD123,319, respectively, on MAPK expression after ischemia-reperfusion in isolated working rat hearts
Nishiyama et al., Kidney Int 2004 (Hypertension, Renal...) : Here, we examined the effect of angiotensin II type 1 receptor (AT1) receptor blockade on renal injury and MAPK activity in Dahl salt-sensitive ( DS ) rats
Li et al., Biochem Pharmacol 2006 : These results suggest that AT1 receptor activated cAMP dependent PKA, PLC and PI 3-kinase signaling is involved in glucagon induced MAP kinase ERK 1/2 phosphorylation in MCs
Godeny et al., Am J Physiol Cell Physiol 2006 : High-affinity binding of angiotensin II (ANG II) to the ANG II type 1 receptor ( AT(1)R ) results in the activation of ERK1/2 mitogen activated protein kinases ( MAPK )
Guo et al., Peptides 2006 (MAP Kinase Signaling System) : Furthermore, AT(1) is required for p38MAPK phosphorylation induced by Ang II
Wei et al., Hypertension 2008 (Disease Models, Animal...) : These data indicate that MAPK plays an important role in the upregulation of AT(1)-R in the rat forebrain in HF and suggest that Ang II upregulates its own receptor by this mechanism
Silva et al., J Renin Angiotensin Aldosterone Syst 2010 : AT1 receptor and NAD ( P ) H oxidase mediate angiotensin II-stimulated antioxidant enzymes and mitogen activated protein kinase activity in the rat hypothalamus
Zhang et al., Am J Physiol Heart Circ Physiol 2012 (MAP Kinase Signaling System) : Aldosterone induced brain MAPK signaling and sympathetic excitation are angiotensin II type-1 receptor dependent ... These data suggest that aldosterone induced sympathetic excitation depends upon that AT(1)R induced MAPK signaling in the brain
Sörensson et al., Biochem J 2012 : Further characterization of one of these new substrates confirmed that At1g80180.1 was phosphorylated in planta in a MAPK dependent manner
Holzmeister et al., Am J Physiol 1997 : The capability of the phorbol ester PMA to activate the human AT1 promoter in VSMC via an AP-1 element suggests a prominent role for PKC/MAPK and Ets proteins in AT1 regulation
Kim et al., Circulation 1998 : These MAPK activations, followed by AP-1 activation, are mediated at least in part by the AT1 receptor
Miyazaki et al., Nihon rinsho. Japanese journal of clinical medicine 1998 (Cardiovascular Diseases) : In contrast, AT1 leads to MAPK activation through PKC in cardiac myocytes
Inagami et al., J Am Soc Nephrol 1999 : In addition to its well known involvement in Gq/11 mediated vasoconstriction and its key roles in the homeostasis of electrolyte balances, the angiotensin II type 1 (AT1) receptor activates mitogen activated protein kinase ( MAPK ) and p42/44 extracellular signal regulated kinase