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IL2 — MAP3K7
Text-mined interactions from Literome
Sun et al., Mol Cell 2004
(Lymphoma, B-Cell, Marginal Zone) :
RNAi mediated silencing of MALT1,
TAK1 , TRAF6, and TRAF2
suppressed TCR dependent IKK activation and
interleukin-2 production in T cells
Sakurai et al., FEBS Lett 2005
:
A specific inhibitor of
TAK1 blocked production of
IL-2 ... In addition, overexpression of
TAK1 and TAB1
induced secretion of
IL-2
Frobøse et al., Mol Endocrinol 2006
:
Suppressor of cytokine Signaling-3
inhibits interleukin-1 signaling by targeting the
TRAF-6/TAK1 complex
Thiefes et al., EMBO Rep 2006
:
YopP, but not the catalytically inactive mutant YopP ( C172A ), also suppresses basal and
interleukin-1-inducible activation of endogenous
TAK1 , TAB1 and TAB2
Inagaki et al., J Biol Chem 2008
:
Tumor necrosis factor- and
interleukin-1 induced
activation of
TAK1 was entirely normal in Tab1-deficient MEFs and could activate both mitogen activated protein kinases and NF-kappaB
Kim et al., PloS one 2009
(Colitis) :
Finally, we showed that
TAK1 is
essential for
interleukin 1- and bacterial components induced expression of cytoprotective factors such as interleukin 6 and cycloxygenase 2