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LTB — PLA2G4A

Text-mined interactions from Literome

Kim et al., J Biol Chem 2002 : These results indicate that a main role of exogenous hVPLA ( 2 ) in neutrophil activation and LTB ( 4 ) biosynthesis is to activate cPLA(2) and 5-lipoxygenase primarily by liberating from the outer plasma membrane lyso-PC that induces [ Ca ( 2+ ) ] ( i ) increase and cPLA(2) phosphorylation and that hVPLA ( 2 ) -induced LTB ( 4 ) production is augmented by the positive feedback activation of cPLA(2) by LTB ( 4 )
Bauldry et al., Biochim Biophys Acta 1996 : This study clearly shows that cPLA2 activation can provide precursors for both LTB4 and PAF, that maximum PAF and LTB4 formation occur under conditions that induced optimal cPLA2 activation, that a close coupling between LTB4 and PAF formation exists, and that, after substrate generation, no additional requirements are necessary for LTB4 and PAF generation in the permeabilized PMN system
Shamsuddin et al., J Lab Clin Med 1997 (Asthma) : With the exception of the greater role for cPLA2 in stimulated LTB4 synthesis in the patients with asthma, the contributions of PLA2 and CoAI-TA to AM LT and PAF synthesis appear to be similar in normal subjects and patients with asthma