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LPA — PLAT

Text-mined interactions from Literome

Beaudeux et al., Life Sci 2001 : The results showed that O2*-/HO* free radical oxidized LDL and Lp(a) led to a dramatic decrease of PAI-1 release but did not affect tPA release, whereas copper oxidation of lipoproteins resulted in an increase in PAI-1 release and a decrease in tPA release ... Thus, the discordant effects of O2*-/HO* oxidized and copper oxidized LDL and Lp(a) on the endothelial releases of PAI-1 and tPA appeared to be due to qualitatively and/or quantitatively different formation of oxidized components by the two oxidation processes
Gugliucci et al., Med Hypotheses 2002 (Diabetes Complications...) : Binding of plasminogen to annexin II is inhibited by Lp (a) and binding of tissue plasminogen activator to annexin II is blocked by homocysteine
Wang et al., Nat Med 2003 (Brain Ischemia) : Lipoprotein receptor mediated induction of matrix metalloproteinase by tissue plasminogen activator
Bas Leerink et al., Thromb Haemost 1992 : In contrast Lp(a)lys+ inhibited Pg activation by tPA in vitro ( IC50 % 20 mg/l ), whereas Lp(a)lys- did not
Mao et al., FEBS Lett 1990 : We confirmed recent reports that Lp(a) is not activated by streptokinase or tissue plasminogen activator (t-PA) to yield plasmin-like activity
Dudani et al., Br J Haematol 1996 : In experiments using anti-actin antibodies added in excess to cultured ECs, binding of plasminogen was inhibited by 45 %, tPA binding was inhibited by 46 % and Lp(a) binding was reduced by 56 %, confirming actin as a binding site for these various ligands whilst attesting to the presence of other EC receptors for these proteins