◀ Back to LEF1
LEF1 — RUNX2
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kahler et al., J Biol Chem 2003
(Osteosarcoma) :
A novel interaction between the DNA binding domains of Runx2 and LEF1 was identified and found crucial for
LEF1 mediated repression of
Runx2 ... A constitutively active beta-catenin enhanced
LEF1 dependent repression of
Runx2
Kahler et al., J Cell Biochem 2006
:
Stable suppression of
Lef1 in MC3T3 preosteoblasts did not
affect proliferation or
Runx2 levels ; however, ALP production and matrix mineralization were accelerated by 3-4 days
Hoeppner et al., J Cell Physiol 2009
:
Runx2 and bone morphogenic protein 2
regulate the expression of an alternative
Lef1 transcript during osteoblast maturation ... We determined that the
Lef1DeltaN p2 promoter is active in osteoblasts and
Runx2 regulates its activity
Mikasa et al., J Bone Miner Metab 2011
:
Runx2 induced Tcf7 and
Lef1 strongly, but Tcf7l1 and Tcf7l2 only slightly in Runx2 ( -/- ) chondrocytes ; the expressions of Tcf7 and Tcf7l2 were reduced in Runx2 ( -/- ) cartilaginous skeletons and calvaria, and Tcf7 showed a similar expression pattern to Runx2