◀ Back to ITCH
CFLAR — ITCH
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Haimerl et al., J Biol Chem 2009
(Drug-Induced Liver Injury...) :
In vitro an artificial knockdown of USP2 inhibited actinomycin D/TNFalpha induced hepatocyte apoptosis, which was associated with elevated levels of the anti-apoptotic protein c-Flip ( L/S ) and a concomitant decrease of cellular levels of the ubiquitinligase
Itch , a negative
regulator of
c-Flip
Schlatter et al., PloS one 2011
:
In contrast to TNFa plus cycloheximide no cFLIP degradation is observed suggesting a different apoptosis pathway in which the
Itch mediated
cFLIP degradation and predominantly caspase-8 activation is not involved