◀ Back to IRF7
IRAK1 — IRF7
Pathways - manually collected, often from reviews:
-
KEGG Toll-like receptor signaling pathway:
IRAK1
→
IRF7
(protein-protein, activation)
-
KEGG Measles:
IRAK1/IRAK4
→
IRF7
(protein-protein, activation)
-
Reactome Reaction:
IRF7
→
IRAK1
(indirect_complex)
Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008
-
Reactome Reaction:
IRF7
→
IRAK1
(reaction)
Marié et al., Mol Cell Biol 2000*, Kawai et al., Nat Immunol 2004, Honda et al., Proc Natl Acad Sci U S A 2004*, Uematsu et al., J Exp Med 2005, Ning et al., Mol Cell Biol 2008
-
WikiPathways Regulation of toll-like receptor signaling pathway:
IRAK1
→
IRF7
(activation)
-
WikiPathways Toll-like Receptor Signaling Pathway:
IRAK1
→
IRF7
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
IRAK1
—
IRF7
(physical association, affinity chromatography technology)
Uematsu et al., J Exp Med 2005
-
IRef Biogrid Interaction:
IRAK1
—
IRF7
(direct interaction, enzymatic study)
Uematsu et al., J Exp Med 2005
-
IRef Biogrid Interaction:
IRAK1
—
IRF7
(direct interaction, fluorescent resonance energy transfer)
Uematsu et al., J Exp Med 2005
-
IRef Biogrid Interaction:
IRAK1
—
IRF7
(physical association, affinity chromatography technology)
Li et al., Immunity 2011
-
IRef Biogrid Interaction:
IRAK1
—
IRF7
(direct interaction, pull down)
Li et al., Immunity 2011
-
IRef Hprd Interaction:
IRAK1
—
IRF7
(in vivo)
Uematsu et al., J Exp Med 2005
-
IRef Innatedb Interaction:
IRF7
—
IRAK1
(unknown, -)
Uematsu et al., J Exp Med 2005
-
IRef Intact Interaction:
Complex of 14 proteins
(association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
-
IRef Intact Interaction:
IRF7
—
IRAK1
(physical association, anti tag coimmunoprecipitation)
Li et al., Immunity 2011
Text-mined interactions from Literome
Schoenemeyer et al., J Biol Chem 2005
:
We also demonstrate that MyD88,
interleukin 1 receptor associated kinase 1, and tumor necrosis factor receptor associated factor 6 are
required for the activation of IRF5 and
IRF7 in the TLR7 signaling pathway
Bruni et al., J Immunol 2013
(Inflammation...) :
Previous work indicated that
IRAK1 negatively
regulates TRIF mediated activation of IRF3 and
IRF7