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INS — TCF7

Text-mined interactions from Literome

Sayo et al., Eur J Biochem 2000 (Insulinoma) : In summary, the results of these studies show that TGF-beta stimulates the transcription of insulin gene and this action is mediated by the transcription factor , PDX-1
Tomizawa et al., J Biol Chem 2000 : The forkhead rhabdomyosarcoma transcription factor ( FKHR ) is a promising candidate to be the transcription factor that binds to the insulin response element of the insulin-like growth factor binding protein-1 ( IGFBP-1 ) promoter and mediates insulin inhibition of IGFBP-1 promoter activity
Goetze et al., J Cardiovasc Pharmacol 2000 : TRO at 1-20 microM potently inhibited insulin stimulated , ERK1/2 dependent Elk-1 transcription factor activity
Marshak et al., Mol Cell Biol 2000 : The PDX-1 transcription factor plays a key role in pancreatic development and in the regulation of the insulin gene in the adult beta cell
Jeschke et al., Mol Med 2002 (Burns...) : Our outcome measures encompassed the effect of insulin on pro- inflammatory cytokines, anti-inflammatory cytokines, and hepatic signal transcription factor mRNA expression ... Pro-inflammatory signal transcription factors STAT-5 and C/EBP-beta mRNA were significantly decreased 1 and 2 days posttrauma ; insulin increased anti-inflammatory signal transcription factor mRNA expression of SOCS-3 and RANTES 7 days after the injury ( p < 0.05 )
Vander Kooi et al., J Biol Chem 2003 (Carcinoma, Hepatocellular) : Surprisingly, IRS 3, as well as IRS 1 and IRS 2, can each confer an inhibitory effect of insulin on the expression of a heterologous fusion gene, indicating that, in this context, a transcription factor other than FKHR, or its orthologs, can also mediate an insulin response through the T ( G/A ) TTTT motif
Santisteban et al., Mol Endocrinol 1992 : Protein-DNA binding studies did not reveal any effect of insulin/IGF-I on the ubiquitous transcription factor and the TTF-1 binding capacity
Stanojevic et al., Endocrinology 2004 (Diabetes Mellitus, Type 2) : The homeodomain transcription factor , pancreas duodenum homeobox (PDX)-1, is essential for pancreas development, insulin production, and glucose homeostasis
Jeschke et al., Endocrinology 2004 (Endotoxemia) : The effects of insulin on hepatic signal transcription factor mRNA expression, proinflammatory and antiinflammatory cytokine mRNA and protein concentration were determined
Orth et al., Regul Pept 2004 : The transcription factor FKHR ( FOXO1a ) is regulated by protein kinase B (PKB) and insulin controls the expression of hepatic genes like glucose-6-phosphatase (G6Pase) at least in part via these proteins
Schisler et al., Proc Natl Acad Sci U S A 2005 : The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose stimulated insulin secretion in islet beta cells
Wolff et al., Cell 2006 : In C. elegans, the sole insulin/IGF-1 receptor, DAF-2, negatively regulates the FOXO transcription factor , DAF-16
Harrison et al., FEBS J 2006 (Adenocarcinoma...) : Insulin induces heme oxygenase-1 through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in renal cells
Yang et al., Mol Cell Biol 2006 (Obesity) : Role of transcription factor NFAT in glucose and insulin homeostasis
Yoshiga et al., Mol Endocrinol 2007 : Insulin induced Akt activation and the phosphorylation of forkhead transcription factor ( FKHR/Foxo1 ), a negative regulator of PPARgamma transcription, were up-regulated by SH2-B overexpression, but reduced in SH2-B-deficient MEFs
Jin et al., Cell Signal 2008 : Extensive examination in different cell lineages has shown that the activity of cat/TCF can be stimulated by mechanisms other than via the Wnt glycoproteins, including the stimulation of beta-cat nuclear translocation and enhanced binding of cat/TCF to the Wnt target gene promoters by insulin and insulin-like growth factor-1 (IGF-1)
Hu et al., Int J Parasitol 2010 : Insulin-like signalling in C. elegans negatively regulates the fork head boxO ( FoxO ) transcription factor encoded by daf-16, which is linked to initiating a dauer-specific pattern of gene expression
Löw et al., Gen Comp Endocrinol 2011 (Nerve Degeneration) : The insulin/IGF-1 receptor inhibits the forkhead transcription factor , FoxO through activating a cascade of conserved kinases
Yecies et al., Cell Metab 2011 : Through unknown mechanisms, insulin activates the sterol regulatory element binding protein ( SREBP1c ) transcription factor to promote hepatic lipogenesis
Nagare et al., J Biol Chem 2011 (Insulin Resistance...) : Overexpression of KLF15 transcription factor in adipocytes of mice results in down-regulation of SCD1 protein expression in adipocytes and consequent enhancement of glucose induced insulin secretion
Dioum et al., Proc Natl Acad Sci U S A 2011 : We previously identified a family of neurogenic 3,5 disubstituted isoxazoles (Isx) that increased expression of neurogenic differentiation 1 ( NeuroD1, also known as BETA2 ) ; this transcription factor functions in neuronal and pancreatic ß-cell differentiation and is essential for insulin gene transcription
Tonks et al., Diabetologia 2013 (Diabetes Mellitus, Type 2...) : Neither insulin sensitivity nor obesity was associated with defective insulin dependent phosphorylation of forkhead box O ( FOXO ) transcription factor
Tsawdaroglou et al., J Steroid Biochem 1989 : We believe that insulin activates an intracellular mediator-transcription factor , that stimulates gene expression indirectly, by interaction with the glucocorticoid receptor
Jacob et al., J Biol Chem 1995 : A consensus insulin response element is activated by an Ets related transcription factor ... The evidence suggests that the insulin responsiveness of these genes is mediated by an Ets related transcription factor
Naya et al., Genes Dev 1995 : Tissue-specific regulation of the insulin gene by a novel basic helix-loop-helix transcription factor
Petersen et al., FEBS Lett 1998 : Glucose stimulated expression of the insulin gene in beta cells is mediated by the PDX-1 transcription factor