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INS — SOCS1
Text-mined interactions from Literome
Ueki et al., Mol Cell Biol 2004
(Endotoxemia...) :
These data indicate that
SOCS-1 and SOCS-3
act as negative regulators in
insulin signaling and serve as one of the missing links between insulin resistance and cytokine signaling
Jamieson et al., J Biol Chem 2005
(Hypoglycemia...) :
Socs1 deficiency
enhances hepatic
insulin signaling
Sachithanandan et al., Diabetes 2011
(Inflammation...) :
Despite the reported
role of
SOCS1 in inhibiting
insulin signaling, it is surprising that a SOCS1 polymorphism that increases SOCS1 promoter activity is associated with enhanced insulin sensitivity despite obesity ... In the current study, we investigated the physiological
role of myeloid and lymphoid cell
SOCS1 in regulating inflammation and
insulin sensitivity
Zhang et al., Diabetes 2012
(Diabetes Mellitus, Type 2...) :
Aß can upregulate suppressors of cytokine signaling
(SOCS)-1 , a well-known
insulin signaling
inhibitor
Kim et al., Biochem J 2012
(Insulin Resistance) :
Interestingly, the expression levels of
SOCS1 ( suppressor of cytokine signalling 1 ) and SOCS3, well-known
insulin signalling
inhibitors , were decreased in ASC-2+/- hepatocytes and increased in ASC-2 overexpressing hepatocytes