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INS — SH2B1

Text-mined interactions from Literome

Duan et al., Mol Cell Biol 2004 (Glucose Intolerance...) : SH2-B , an Src homology 2 (SH2) and pleckstrin homology domain containing adaptor protein, binds via its SH2 domain to insulin receptor in response to insulin ; however, its physiological role remains unclear
Li et al., Endocrinology 2006 (Body Weight...) : SH2-B and APS, two members of a pleckstrin homology and SH2 domain containing adaptor family, promote both insulin and leptin signaling in a similar fashion in cultured cells
Li et al., Endocrinology 2007 : In mice, SH2B1 regulates energy and glucose homeostasis by enhancing leptin and insulin sensitivity
Rider et al., Mol Endocrinol 2009 : The Src homology 2 (SH2) domain containing adapter protein SH2B1beta plays a role in severe obesity, leptin and insulin resistance, and infertility
Morris et al., Diabetes 2009 (Insulin Resistance) : Insulin stimulated the binding of SH2B1 to IRS-1 or IRS-2