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Zhong et al., Biochem Biophys Res Commun 2002 : Insulin ( 1-100 nM ) produced a concentration dependent increase in resistin secretion from 3T3-L1 adipocytes ( 1 nM-42 %, 10nM-55 %, and 100 nM-86 % vs. control ) ... Insulin stimulated resistin secretion ( 100 nM ) was almost completely inhibited ( 94 % ) by ET-1 ( 100 nM ) ... In conclusion, our studies demonstrate that basal and hormonal stimulation of resistin secretion by insulin are inhibited by ET-1
Viengchareun et al., FEBS Lett 2002 : Insulin and thiazolidinedione, a peroxisome proliferator activated receptor gamma agonist, stimulated resistin expression two- to four-fold in differentiated T37i cells, whereas adiponectin mRNA levels increased 1.5-2-fold
Kawashima et al., Diabetologia 2003 : This study was designed to examine the effect and mechanism ( s ) of insulin on resistin expression in 3T3-L1 adipocytes
McTernan et al., J Clin Endocrinol Metab 2003 (Diabetes Mellitus, Type 2) : Resistin and type 2 diabetes : regulation of resistin expression by insulin and rosiglitazone and the effects of recombinant resistin on lipid and glucose metabolism in human differentiated adipocytes ... Therefore, the aims of this study were to analyze serum resistin concentrations in type 2 diabetic subjects ; to determine the in vitro effects of insulin and rosiglitazone ( RSG ) on the regulation of resistin , and to examine the functional effects of recombinant human resistin on glucose and lipid metabolism in vitro ... However, in vitro, insulin stimulated resistin protein secretion in a concentration dependent manner in adipocytes [ control, 1215 +/- 87 pg/ml ( mean +/- SEM ) ; 1 nM insulin, 1414.0 +/- 89 pg/ml; 1 microM insulin, 1797 +/- 107 pg/ml ( P < 0.001 ) ] ... RSG ( 10 nM ) reduced the insulin mediated rise in resistin protein secretion ( 1 nM insulin plus RSG, 971 +/- 35 pg/ml ; insulin, 1 microM insulin plus RSG, 1019 +/- 28 pg/ml ; P < 0.01 vs. insulin alone )
Ng et al., J Clin Endocrinol Metab 2004 (Diabetes Mellitus, Type 1...) : The suppressive effect of insulin on resistin may partially explain the excess accumulation of adipose tissue in infants of diabetic mothers by reducing the inhibitory effect of resistin on adipogenesis
Steppan et al., Mol Cell Biol 2005 (Insulin Resistance) : SOCS-3 induction is the first cellular effect of resistin that is independent of insulin and is a likely mediator of resistin 's inhibitory effect on insulin signaling in adipocytes
Munir et al., J Clin Endocrinol Metab 2005 (Hyperandrogenism...) : Resistin ( > or =1 ng/ml ) augmented forskolin and forskolin plus insulin stimulation of CYP17 mRNA expression in a concentration dependent manner
Lappas et al., J Endocrinol 2005 (Diabetes, Gestational) : Insulin increased placental resistin release, whereas the hormones dexamethasone, progesterone and estrogen significantly decreased placental resistin release
Filippidis et al., Blood Purif 2005 (Insulin Resistance...) : Resistin , a recently discovered insulin inhibitor secreted by adipocytes, is associated with obesity and insulin resistance in mice
Rea et al., Diabetes Obes Metab 2006 : Insulin 1 microm and rosiglitazone 10 microm markedly reduced resistin mRNA expression ( relative to the control gene TF2D ) by 4.7-fold ( p < 0.05 ) and 5.3-fold ( p < 0.02 ), respectively ... In the absence of insulin , however, resistin increased glucose uptake dose-dependently ( e.g., 1.75-fold at 5 microm, p < 0.001 ) via a mitogen activated protein kinase dependent pathway
Shen et al., J Biol Chem 2006 (Cardiovascular Diseases...) : In the current study, we observed that resistin inhibited insulin signaling and eNOS activation in endothelial cells ... In summary, up-regulation of PTEN is involved in the inhibitory effects of resistin on insulin signaling and eNOS activation in endothelial cells ... Our findings suggest that resistin mediated inhibition of insulin signaling and eNOS activation may contribute to cardiovascular diseases
Birkás Kováts et al., Neuropsychopharmacol Hung 2005 (Insulin Resistance...) : Role of ghrelin ( RIA ), resistin and TNF-alpha ( ELISA ) in weight gain and insulin resistance ( fasting plasma insulin, HOMA, ELISA ) was studied in Hungarian psychiatryic patients ( n=60 ) treated with SGA ( clozapine, olanzapine, risperidone, quetiapine, 15 each )
Niederwanger et al., Mol Cell Endocrinol 2007 : The rate of glucose-6-phosphate formation, however, was decreased by resistin both in the absence and presence of insulin ; in the absence of insulin, resistin decreased glucose-6-phosphate formation by reducing hexokinase type I activity without affecting glucose uptake ; by contrast, in the presence of insulin , resistin decreased glucose-6-phosphate formation by reducing the Vmax of glucose uptake without changing hexokinase type I activity
Nakata et al., Biochem Biophys Res Commun 2007 (Insulin Resistance) : Resistin induces insulin resistance in pancreatic islets to impair glucose induced insulin release
Lin et al., Chin Med Sci J 2007 (Cerebral Infarction...) : To analyze the role of resistin in insulin resistance (IR) through investigating the variation of plasma resistin levels and single-nucleotide polymorphisms ( SNPs ) in resistin gene 5 ' flanking region in stroke patients
Brown et al., FEBS Lett 2007 : This study investigated the effects of resistin on insulin secretion, insulin receptor expression and cell viability in pancreatic beta-cells
Wölfing et al., Exp Clin Endocrinol Diabetes 2008 : Insulin significantly stimulates adiponectin and resistin secretion under normo- and hyperglycemia
Park et al., Endocrinology 2008 (Body Weight...) : Unlike leptin, resistin significantly increased first-phase insulin secretion during hyperglycemic clamp and beta-cell mass by augmenting beta-cell proliferation ... Leptin enhanced insulin signaling by potentiating IRS2 -- > Akt pathways, whereas resistin activated Akt without augmenting insulin receptor substrate 2 phosphorylation
Liu et al., Acta Pharmacol Sin 2008 (Insulin Resistance) : SOCS-3 induction may contribute to the resistin mediated inhibition of insulin signaling in H4IIE hepatocytes
Liu et al., World J Gastroenterol 2008 (Insulin Resistance...) : To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro ... This cellular differentiation stimulated resistin expression and secretion, but was suppressed by insulin ... Insulin can inhibit resistin expression and secretion in vitro, but insulin is not a major regulator of resistin in vivo
Sheng et al., Endocrine 2008 (Insulin Resistance) : Here, we investigate the relationship between human resistin and insulin resistance in hepatocytes and the effect of Metformin on resistin
Qi et al., Eur J Endocrinol 2008 (Diabetes Mellitus, Type 2...) : Resistin increases insulin resistance (IR) in mice
Gao et al., Mol Biol Rep 2009 (Insulinoma) : Resistin , an adipokine linked obesity with type 2 diabetes, impairs glucose stimulated insulin secretion ( GSIS ) in beta-cells
Duffy et al., J Trauma 2009 (Burns) : We suggest that postburn insulin function is adversely affected by resistin produced as a result of this monocyte activation
Do Carmo et al., Am J Physiol Endocrinol Metab 2009 (Fatty Liver...) : This impaired insulin response is not caused by a decrease in circulating leptin or a modulation of adiponectin and resistin levels
Junkin et al., Am J Physiol Regul Integr Comp Physiol 2009 : However, there has been little investigation of the effects of resistin on fatty acid ( FA ) metabolism and insulin response in skeletal muscle, a key tissue for glucose disposal
Jørgensen et al., Am J Physiol Endocrinol Metab 2009 : Here, we examined the effect of oligomerized human resistin on insulin signaling and glucose metabolism in skeletal muscle and myotubes ... Resistin did not impair TBC1D4 phosphorylation but did reduce both insulin and AICAR stimulated GLUT4 plasma membrane translocation
Luo et al., Endocrine 2009 (Carcinoma, Hepatocellular...) : This study investigated the effect of resistin on glucose metabolism and insulin signaling using human recombinant resistin and small interfering RNA ( siRNA ) against AMPKalpha2 to treat the human liver HepG2 cells
Tarkowski et al., J Cell Mol Med 2010 : This may partly explain the multifunctional role of resistin in chronic inflammation, atherosclerosis and insulin resistance
Wu et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009 (Leukemia) : Although the effect of mouse resistin on insulin-resistance has been well defined, but the biological function of human resistin is still unknown
Wohl et al., Eur J Endocrinol 2010 (Glucose Intolerance...) : Insulin stimulated plasma adiponectin ( P < 0.05 ), leptin and resistin ( P < 0.001 ) were increased, whereas TNFa was decreased ( P < 0.05 ) after telmisartan treatment ... Telmisartan increases plasma leptin as well as insulin stimulated plasma adiponectin, leptin and resistin , and decreases plasma TNFa during HEC
Stan et al., Cell Tissue Res 2011 (MAP Kinase Signaling System) : We found that ( 1 ) the gene expression and protein level of resistin were up-regulated by HG ; ( 2 ) the inhibitors of the mitogen activated protein kinases ( MAPKs ) p38 ( SB203580 ), extracellular signal regulated kinases 1/2 ( ERK1/2 ; PD98059 ) and c-Jun N-terminal kinase ( SP600125 ) and of the transcription factor nuclear factor kappa-B ( PDTC ) inhibited HG-induced resistin protein production and ( 3 ) insulin reduced HG-induced resistin expression via a mechanism independent of phosphatidylinositol 3-kinase (PI3K) or p38 and ERK1/2
D'Elia et al., International journal of nephrology and renovascular disease 2009 : Fatty acid accumulation and resistin inhibit insulin and adiponectin
Zhou et al., Hepatology 2013 (Disease Models, Animal...) : In this study, we discovered that resistin down-regulated the content and activities of mitochondria, enhanced hepatic steatosis, and induced insulin resistance (IR) in mice