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INS — PRL

Text-mined interactions from Literome

Goda et al., Endocr J 1998 : We also labeled MtT/S cells with BrdU for 24 h during PRL producing cell induction by insulin and EGF, and as a result BrdU labeled proliferative cells were specifically absent from PRL producing cell populations
Barash et al., Mol Cell Endocrinol 1999 : In the presence of insulin , PRL induced MAP kinase activity, initiated at a comparable rate to that of PHAS-I phosphorylation
Petryk et al., J Endocrinol 2000 (Insulinoma...) : Prolactin induction of insulin gene expression : the roles of glucose and glucose transporter-2 ... Since glucose independently stimulates beta-cell replication and insulin production, it is unclear whether the effects of prolactin (PRL) on insulin gene expression are exerted directly or through the uptake and/or metabolism of glucose ... These observations suggested that PRL exerts glucose independent as well as glucose dependent effects on insulin gene expression
Fruchtman et al., Endocrinology 2000 : IGF-II and insulin also increased PRL release, but only at 10-fold higher concentrations than the lowest effective IGF-I dose
Kopelman et al., International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2000 (Body Weight...) : Prolactin in this circumstance appears to be marker of hypothalamic-pituitary function : the prolactin response to insulin-hypoglycaemia , thyrotrophin releasing hormone stimulation and other stimulatory factors may be diminished
Friedrichsen et al., Mol Endocrinol 2001 (Insulinoma...) : GH and PRL stimulate proliferation and insulin production of pancreatic beta-cells ... Whereas GH- and PRL regulated transcription of the insulin gene in insulinoma cells has been shown to depend on STAT5 ( signal transducer and activator of transcription 5 ), the signaling pathways involved in GH/PRL induced beta-cell replication are unknown
Jacob et al., Mol Cell Endocrinol 2002 : Prolactin-CAT expression was increased 12-fold in cells transfected with wild type insulin receptor, but insulin did not increase prolactin gene expression when a kinase negative mutant of the ATP binding site ( K1030R ) was expressed
Broglio et al., J Clin Endocrinol Metab 2002 : CST-14 and SS-14 do not affect PRL and ACTH secretion but, like ghrelin, inhibit insulin secretion ; the ghrelin induced inhibition is not additive with that of CST-14 or SS-14, suggesting a common mechanism of action on beta cell secretion
Weiss et al., Arch Gynecol Obstet 2003 (Calcium Signaling) : In the present study we tested the hypothesis that insulin might affect LH or prolactin secretion of cultured female rat pituitary cells
Tian et al., Mol Cell Endocrinol 2003 : Prolactin regulates adenylyl cyclase and insulin secretion in rat pancreatic islets ... Thus, PRL not only increased islet AC expression and activity and insulin secretory responsiveness, but also protected islets from chronic glucose induced inhibition of these beta-cell activation parameters
Rillema et al., Experimental biology and medicine (Maywood, N.J.) 2003 : Insulin alone, as well as PRL in the presence of insulin and cortisol, was shown to stimulate uridine uptake and incorporation into RNA in mammary explants taken from 12- to 14-day pregnant mice
Amaral et al., Horm Metab Res 2003 : PRL significantly potentiated glucose induced insulin secretion in islets cultured for 7 days
Reiter et al., Mol Cell Endocrinol 1992 : Growth hormone and prolactin stimulate androgen receptor, insulin-like growth factor-I (IGF-I) and IGF-I receptor levels in the prostate of immature rats
Julie et al., Endocr Res 2003 : The role of luteinizing hormone and prolactin in the regulation of insulin receptors in Leydig cells of the adult rat
Jensen et al., J Endocrinol 2005 : We have previously found that GH and prolactin (PRL) stimulate both proliferation and insulin production in pancreatic beta-cells and rat insulin producing INS-1 cells
Stanley et al., J Biol Chem 1992 (Pituitary Neoplasms) : An element in the prolactin promoter mediates the stimulatory effect of insulin on transcription of the prolactin gene ... The insulin-sensitive DNA binding factor may mediate effects of insulin on prolactin gene transcription
Rojkittikhun et al., Acta Physiol Scand 1991 : The possible role of prolactin in modulating insulin , glucagon and glucose concentrations as well as the possibility that oxytocin affects gastrin and somatostatin levels following weaning are discussed
Jackerott et al., Diabetes 2006 (Diabetes Mellitus, Experimental...) : Pancreatic beta-cell growth and survival and insulin production are stimulated by growth hormone and prolactin through activation of the transcription factor signal transducer and activator of transcription ( STAT ) 5
Weinhaus et al., J Endocrinol 2007 : Regulation of glucokinase in pancreatic islets by prolactin : a mechanism for increasing glucose stimulated insulin secretion during pregnancy
Stanley et al., Endocrinology 2007 : Finally, small interfering RNA mediated reduction of PAK decreased the effect of insulin on prolactin gene expression
Parthasarathy et al., Mol Cell Endocrinol 2008 : Our results show that metyrapone induced corticosterone deficiency impairs Leydig cell insulin and prolactin receptors, and their mRNA expression and the response of Leydig cells to LH/PRL/insulin on testosterone production
Brelje et al., J Endocrinol 2008 : Beneficial effects of lipids and prolactin on insulin secretion and beta-cell proliferation : a role for lipids in the adaptation of islets to pregnancy
Hugo et al., J Clin Endocrinol Metab 2008 (Obesity) : Insulin suppressed PRL expression and release from differentiated adipocytes but moderately stimulated PRL release from nondifferentiated cells
Weaver et al., Clin Endocrinol (Oxf) 1991 (Obesity, Morbid) : The following were measured : fasting insulin, relative insulin resistance calculated using fasting insulin and plasma glucose by the homeostatic model of assessment, insulin release during a 75-g oral glucose tolerance test ( insulin area under the curve ), steady-state plasma glucose level achieved during a simultaneous intravenous infusion of dextrose, insulin and somatostatin, and the prolactin and growth hormone (GH) responses to insulin induced hypoglycaemia
Huang et al., Endocrinology 2009 (Glucose Intolerance) : Prolactin (PRL) can enhance beta-cell proliferation and insulin secretion in vitro, yet whether it is PRL or other pregnancy related factors that mediate these adaptive changes during pregnancy is unknown
Keech et al., Mol Cell Endocrinol 1991 (Pituitary Neoplasms) : Insulin activation of rat prolactin promoter activity ... The role of insulin regulation of rat prolactin ( rPRL ) gene transcription was studied using GH4 rat pituitary tumor cells transiently transfected with plasmids containing proximal rPRL promoter fragments ligated to the reporter gene luciferase
Karthikeyan et al., Reprod Biol 2009 : The effects of prolactin and corticosterone on insulin binding to rat Leydig cells
Arumugam et al., Endocrinology 2010 : Prolactin (PRL) induces beta-cell proliferation and glucose stimulated insulin secretion ( GSIS ) and counteracts the effects of glucocorticoids on insulin production
Handwerger et al., Ann N Y Acad Sci 1991 : In addition, the synthesis and release of decidual prolactin are stimulated by IGF-I, insulin and relaxin, each acting through distinct plasma membrane receptors ... The demonstration that the synthesis and release of decidual prolactin are regulated by PRL-RF, IGF-I, insulin , relaxin, arachidonic acid, PRL-IF and lipocortin I strongly suggests that there is novel autocrine/paracrine feedback regulation between the placenta, fetal membranes, and decidua in the regulation of decidual prolactin
Thomas et al., Endocrinology 1989 : Plasma PRL responses to insulin in SHAM ewes were completely abolished, and the plasma PRL response to chlorpromazine was reduced to almost half by LESION ... In addition, the PRL response to insulin is dependent on a functional posterior pituitary gland, whereas responses to audiovisual stress and serotonin appear to rely on inputs to the pituitary gland via the median eminence and the long hypothalamo-hypophysial portal blood vessels
Willenbring et al., Psychoneuroendocrinology 1989 (Opioid-Related Disorders...) : Our results in the methadone group suggest ( a ) near-maximal stimulation of prolactin secretion, with a blunted prolactin response to insulin hypoglycemia, ( b ) mild suppression of cortisol levels, but an exaggerated cortisol response to stimulation, ( c ) a delayed and inhibited insulin response to food ingestion with resulting mild hyperglycemia, ( d ) low body weight, but elevated calorie ingestion, and ( e ) inability to concentrate urine when dehydrated, which was partially corrected by administration of arginine vasopressin
Thrailkill et al., Endocrinology 1989 : Insulin stimulates the synthesis and release of prolactin from human decidual cells ... To determine whether insulin regulates the synthesis and secretion of decidual PRL , monolayer cultures of human decidual cells were exposed to insulin at concentrations ranging from 10 ng to 10 micrograms/ml for up to 5 days ... Insulin stimulated a dose dependent increase in PRL release ( half-maximal concentration, 50 ng/ml ), beginning 48 h after initial exposure ... Insulin also stimulated de novo PRL synthesis
Stanley et al., J Biol Chem 1988 (Pituitary Neoplasms) : Insulin stimulated prolactin mRNA levels and gene transcription rates to the same extent as the prolactin production rates
Masala et al., J Clin Endocrinol Metab 1979 : Enhancement of insulin induced prolactin secretion by fluoxetine in man ... Fluoxetine hydrochloride, a specific inhibitor of serotonin reuptake, was given orally to five adult males to study its effect on fasting and insulin stimulated release of PRL ... Fluoxetine significantly enhanced insulin induced PRL release ... These data suggest that serotoninergic pathways have little or no part in the control of spontaneous PRL secretion in man, whereas they may play a role in insulin stimulated PRL release
Karibe et al., Acta Psychiatr Scand 1988 (Hypoglycemia) : We investigated PRL responses to TRH ( 500 micrograms ) and insulin ( 0.1 U/kg ) in 19 women with AN and 10 normal women
Prager et al., Endocrinology 1988 (Pituitary Neoplasms) : Insulin regulates prolactin secretion and messenger ribonucleic acid levels in pituitary cells ... Insulin ( 0.7 nM ) stimulated PRL production by 30 %, and cortisol ( 100 nM ) suppressed it by 80 % in GH3 cells ... Insulin ( 3.5 nM ) partially blocked the suppression of PRL secretion induced by up to 100 nM cortisol ... Physiological doses of insulin stimulate PRL production and PRL mRNA levels, suggesting a direct effect of insulin on either PRL gene transcription or stabilization of PRL mRNA in these cells
Sorenson et al., Endocrinology 1987 : Prolactin ( in vitro ) decreases the glucose stimulation threshold, enhances insulin secretion, and increases dye coupling among islet B cells
Sadovnikova et al., Probl Endokrinol (Mosk) 1985 : A study was made of the STH and prolactin effect on insulin secretion and 3H-thymidine incorporation in DNA by keeping them in 10.5 and 1 % embryonic calf serum using a model of the primary monolayer culture of isolated pancreatic islet cells
Everett et al., Arch Intern Med 1979 (Giant Cell Arteritis...) : The failure of growth hormone and prolactin to respond to insulin hypoglycemia and an inadequate prolactin response to the administration of chlorpromazine provided further evidence of hypopituitarism
Goodyer et al., Endocrinology 1984 : To determine the direct effects of insulin-like growth factors (IGFs) on pituitary secretion of GH, PRL , and ACTH, adult male rat pituitary explant cultures were tested with acute ( 3-4 h ) or chronic ( 24 h ) exposure to a semipurified preparation of IGF peptides, free of immunoreactive insulin, containing IGF-I and IGF-II in a ratio of approximately 1 : 4
Serri et al., J Clin Endocrinol Metab 1981 : To evaluate the role of endogenous opiates on the regulation of the pituitary hormonal stress response, we have studied in six normal subjects the insulin induced secretion of PRL , GH, and ACTH with and without naloxone, a specific opiate antagonist
Sizemore et al., In Vitro 1982 (Mammary Neoplasms, Experimental...) : Insulin greatly enhanced protein synthesis, but glucocorticoid and prolactin did not further increase the rate
Harvey et al., J Endocrinol 1978 : No consistent effect of insulin on the secretion of prolactin was observed
Stahnke et al., Eur J Pediatr 1984 (Craniopharyngioma...) : After craniotomy their basal and TRH stimulated prolactin levels were in the normal range, but their insulin secretion was markedly increased
Landgraf-Leurs et al., Klin Wochenschr 1984 (Hypoglycemia...) : At 0.075 IU/kg human insulin induced significantly less prolactin release than porcine insulin
Adler et al., Life Sci 1983 (Hypoglycemia) : Both insulin induced hypoglycemia and fasting decreased serum PRL in control rats, but the AP-implanted animals manifested a rise in serum PRL in response to these stimuli
Waldhauser et al., J Clin Endocrinol Metab 1984 (Body Weight) : Diminished prolactin response to thyrotropin and insulin in anorexia nervosa
Godden et al., Horm Metab Res 1984 (Hyperthyroidism) : T4 treatment did not affect the prolactin response to TRH injection or the insulin and glucose responses to glucagon injection
Flint et al., J Endocrinol 1984 : Effects of prolactin , progesterone and ovariectomy on metabolic activities and insulin receptors in the mammary gland and adipose tissue during extended lactation in the rat ... Prolactin prevented the increase in insulin receptors and lipid synthesis and significantly decreased LPL activity in adipose tissue
Skarda et al., Reprod Nutr Dev 1982 : These data suggest that insulin , prolactin and cortisol are involved in the maintenance of goat mammary tissue in culture but that prolactin essentially stimulates milk synthesis
Mendelson et al., J Clin Endocrinol Metab 1981 : Piperidine did not affect the daytime insulin induced secretion of either GH or PRL , as assessed by an analysis of variance
Kletzky et al., Clin Endocrinol (Oxf) 1980 (Hypoglycemia) : Effects of cyproheptadine on insulin induced hypoglycaemia secretion of PRL , GH and cortisol
Bolander et al., Proc Natl Acad Sci U S A 1981 : In addition, these effects do not reflect a specific insulin requirement for prolactin sensitivity ; epidermal growth factor can support prolactin induced total RNA synthesis as well as insulin can
Flint et al., J Endocrinol 1982 : Regulation of insulin receptors by prolactin in lactating rat mammary gland
Valk et al., Clin Endocrinol (Oxf) 1981 : The 24-h plasma prolactin profile was unchanged as was the prolactin response to insulin and TRH stimulation
Tepavcević et al., J Endocrinol Invest 1995 (Hypoglycemia) : The role of serotonin in the insulin hypoglycemia (IH) stimulated secretion of prolactin (PRL) , growth hormone (GH), adrenocorticotropin ( ACTH ) and cortisol ( F ) was studied in a group of 12 normal subjects during the control period after placebo and a consecutive six-day treatment with 20 mg ritanserin (RIT) per day
Jacob et al., Mol Cell Endocrinol 1995 (Pituitary Neoplasms...) : Insulin and cAMP stimulate prolactin gene transcription and prolactin-CAT expression in rat pituitary tumor GH cells
Meza et al., J Gen Physiol 1994 : In rat pituitary GH3 cells, epidermal growth factor (EGF) and insulin stimulate prolactin production, whereas glucocorticoids exert the opposite effect
Nishikawa et al., Am J Physiol 1994 : PRL-RL and beta-casein mRNA levels in cultured mammary epithelium increased in response to insulin , hydrocortisone, and prolactin, whereas progesterone or EGF caused inhibition
Baumrucker et al., J Endocrinol 1994 : Both insulin and prolactin concentrations exhibited a transient increase in blood at the first feeding, but insulin increased with the MR- treatment whereas prolactin increased with the MR+ treatment
Dodd et al., J Dairy Res 1994 : Prolactin increased alpha-lactalbumin accumulation to a similar extent alone, or in the presence of insulin and/or corticosterone
Sorenson et al., Endocrinology 1993 : These results demonstrate that progesterone counterregulates the effects of PRL on insulin secretion and islet beta-cell division
Sinha et al., Proc Soc Exp Biol Med 1993 : This in vitro study examined the differential effects of glycosylated and nonglycosylated porcine PRL on cell division and insulin secretion from neonatal rat islets, and compared these results with those produced by homologous rat PRL
Nowak et al., J Clin Endocrinol Metab 1993 (Leiomyoma...) : 17 beta-Estradiol, progesterone, TRH, insulin-like growth factor-I, epidermal growth factor, and the GnRH agonist leuprolide did not affect PRL secretion by these SMC ... Insulin caused a significant suppression of PRL secretion by 72 h, and this was accompanied by a 64 % increase in total cell protein per well, which represented an increase in cell number
Lochnan et al., Mol Cell Endocrinol 1995 : Human placental lactogen and bovine PRL could also induce a greater than 10-fold induction, whereas insulin did not significantly stimulate the beta-casein promoter
Matsuda et al., Proc Soc Exp Biol Med 1996 (Glucose Intolerance...) : The effects of prolactin (PRL) on circulating levels of glucose and insulin , and of estradiol on hyperprolactinemia induced glucose intolerance of tissues were studied in pituitary grafted SHN mice ( PG mice ) and sham operated controls
Galsgaard et al., Mol Endocrinol 1996 (Insulinoma) : GH and PRL stimulate both proliferation and insulin production in pancreatic beta-cells as well as in the rat insulinoma cell line RIN-5AH, We report here that human GH increases insulin mRNA levels in RIN-5AH cells via both somatogenic and lactogenic receptors
McMahon et al., Domest Anim Endocrinol 1997 (Body Weight) : Prolactin does not enhance glucose stimulated insulin release in red deer stags ... It is concluded that elevated levels of prolactin in summer do not enhance the release of insulin to glucose in red deer
Stout et al., Endocrinology 1997 : The effects of PRL on cell division and insulin secretion were glucose dependent
Matsuda et al., Zoolog Sci 1997 : PRL ( 1 microgram/ml ) significantly increased the insulin secretion and the amount of PRL-R mRNA relative to that of beta-actin mRNA
Ratovondrahona et al., J Mol Endocrinol 1998 : Our studies showed that PRL induces rapid increases in the production of Ins ( 1,3,4,5 ) P4 ( 207 % at 30 s ), InsP5 ( 171 % at 30 s ), and InsP6 ( 241 % at 30 s )
Rovenský et al., Lupus 1998 (Lupus Erythematosus, Systemic) : Insulin induced plasma PRL and GH were significantly increased both in patients and healthy subjects ; however, the increments or areas under the curves were not different in the two groups
Flores et al., Comp Biochem Physiol C Pharmacol Toxicol Endocrinol 1998 : Glucagon ( 1 microM ), ACTH ( 2.5 microM ), human and bovine growth hormone ( 4.6 and 2.1 microM ), prolactin ( 0.27 microM ), corticosterone ( 0.4 microM ), androstanolone ( 10 ( -2 ) microM ), estradiol and estrone ( 10 microM ), triiodothyronine and thyroxine ( 1 microM ) enhanced significantly the glucose induced insulin secretion