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INS — POMC
Text-mined interactions from Literome
Breen et al., Brain Res 2005
:
Agouti related protein (AGRP) and
proopiomelanocortin (POMC) have opposing effects on melanocortin receptor ( MC-R ) signaling and energy balance, and are important
targets for leptin and
insulin in the hypothalamus
Nedungadi et al., Neuroendocrinology 2007
(Hypoglycemia) :
Effects of estradiol on acute and recurrent
insulin induced hypoglycemia associated patterns of arcuate neuropeptide Y,
proopiomelanocortin , and cocaine- and amphetamine related transcript gene expression in the ovariectomized rat
Hirosawa et al., Biochem Biophys Res Commun 2008
(Diabetes Mellitus...) :
Ablation of estrogen receptor alpha (ERalpha) prevents
upregulation of
POMC by leptin and
insulin
Keen-Rhinehart et al., Horm Behav 2009
:
Consistent with this, central
insulin decreased hypothalamic NPY and AgRP and
increased POMC mRNA expression
Hill et al., Endocrinology 2009
(Obesity) :
This regulation involves proopiomelanocortin (POMC) neurons because suppression of phosphatidyl inositol 3-kinase (PI3K) signaling in these neurons blunts the acute
effects of
insulin and leptin on
POMC neuronal activity
Relling et al., J Anim Sci 2010
(Body Weight) :
We conclude that
insulin , ghrelin, CCK, and GLP-1 may
regulate DMI in sheep by regulating the hypothalamic gene expression of NPY, AgRP, and
POMC
Williams et al., J Neurosci 2010
:
Interestingly, both
insulin and leptin
regulate POMC cellular activity by activation of PI3K ; however, it is unclear whether leptin and insulin effects are observed in similar or distinct populations of POMC cells
Zhang et al., Eur J Neurosci 2011
(Body Weight...) :
Relative to pair feeding,
POMC caused sustained weight reduction and additional fat loss, lowered fasting
insulin and glucose, and augmented white fat hormone-sensitive lipase activity and brown fat uncoupling protein 1 level
Relling et al., J Anim Physiol Anim Nutr (Berl) 2012
:
Results of the present study are consistent with the concept that effects of propionate on feed intake in ruminants is not mediated through direct effects on the hypothalamus, and that
insulin is
required for an effect of glucose on hypothalamic
POMC expression