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INS — PCSK1

Text-mined interactions from Literome

Costanzo et al., Diabetes 2001 : This interaction was greater for the Q allele than for the K allele ( P < 0.01 ), suggesting that direct PC-1-IR interactions are important for the PC-1 inhibitory effect on insulin signaling
Frittitta et al., Diabetes 2001 (Diabetes Mellitus...) : Glycoprotein PC-1 inhibits insulin signaling and, when overexpressed, plays a role in human insulin resistance
Menzaghi et al., Am J Physiol Endocrinol Metab 2003 : Insulin induced a fourfold increase ( P < 0.01 ) of membrane PC-1 expression by rapid and sensitive mechanism ( s )
Wideman et al., Proc Natl Acad Sci U S A 2006 (Diabetes Mellitus, Experimental) : Here, we show that adenovirus mediated expression of PC1/3 in alpha cells increases islet GLP-1 secretion, resulting in improved glucose stimulated insulin secretion and enhanced survival in response to cytokine treatment
Ahlqvist et al., Diabetologia 2012 (Diabetes Mellitus, Type 2...) : A common variant in PAX6 is associated with reduced PAX6 and PCSK1 expression in human islets and reduced insulin response , as well as decreased glucagon and GIP concentrations and decreased insulin sensitivity
Shannon et al., Respir Physiol 1983 : Intercostal nerve stimulation (INS) of sufficient intensity to reduce PA also reduced the activity of phasic PC I-neurons and the I-modulated portion of tonic firing I-neurons
Youngren et al., Diabetes 1996 (Diabetes Mellitus...) : Membrane glycoprotein PC-1 , an inhibitor of insulin signaling, produces insulin resistance when overexpressed in cells transfected with PC-1 cDNA
Frittitta et al., Diabetes 1998 (Insulin Resistance) : Membrane glycoprotein PC-1 inhibits insulin receptor (IR) tyrosine kinase activity and subsequent cellular signaling