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Leuner et al., Z Gerontol Geriatr 2012 (Obesity...) : The absence of RAGE resulted in accelerated weight gain, increased plasma cholesterol, and higher insulin levels in obese mice
Monden et al., Diabetes 2013 (Body Weight...) : In this study, we examined mechanisms underlying how RAGE regulates adiposity and insulin sensitivity
Lam et al., Diabet Med 2013 (Diabetes Mellitus, Type 1) : In vitro, insulin increased esRAGE and total RAGE isoform expression in cell lysate on a western blot, and reverse transcription-polymerase chain reaction showed an increase in esRAGE and full-length RAGE mRNA ... Pretreatment of THP-1 cells with a general metalloproteinase inhibitor GM6001 significantly reduced the production of sRAGE, suggesting that insulin also increased the cleavage of full-length cell surface RAGE to form sRAGE ... In vitro, insulin not only increases both full-length RAGE and esRAGE expression, but can also stimulate the shedding of sRAGE from the membrane bound receptor