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INS — MMP9

Text-mined interactions from Literome

Fischoeder et al., Cardiovasc Res 2007 (Insulin Resistance) : The aim of this study was to investigate the regulation of monocyte MMP-9 by insulin ... Stimulation of MMP-9 expression by insulin was time- and concentration dependent in human monocytic THP-1 cells ... Inhibition of insulin receptor (IR) maturation via inhibition of its activating convertase furin with the pharmacological furin-inhibitor decanoyl-RVKR-chloromethylketone, as well as blocking of IGF-1R function with a IGF-1R blocking antibody, demonstrated that insulin mediates increases in MMP-9 via IR activation ... Inhibition of insulin 's `` metabolic '' phosphatidylinositol 3-kinase signaling with wortmannin ( 50 nmol/L ) or LY294002 ( 2.5 micromol/L ) did not prevent insulin dependent MMP-9 induction ... In contrast inhibition of insulin 's `` mitogenic '' Ras-Raf-mitogen activated protein kinase-kinase pathways with PD98059 ( 15 micromol/L ) or U0126 ( 2 micromol/L ) inhibited insulin induced MMP-9 gelatinolytic activity in THP-1 cells ... This study demonstrates that insulin can induce MMP-9 via mitogenic signaling pathways in monocytes, whereas phosphatidylinositol 3-kinase dependent signaling, typically altered in insulin resistance, is not required ... Induction of MMP-9 by insulin may potentially contribute to a pro-inflammatory state and the increased cardiovascular morbidity and mortality in type 2 diabetics
Kappert et al., Biochem Biophys Res Commun 2008 (Hyperinsulinism...) : In line with this, pioglitazone inhibited Erk1/2-phosphorylation and subsequent insulin dependent MMP-9 synthesis in THP-1 cells ... Thus, insulin increases MMP-9 gelatinolytic activity in monocytic cells, which results in accelerated chemotaxis
Boden et al., Diabetes 2008 (Hyperinsulinism) : FFA augmented the insulin mediated increases in MMP-2 ( from approximately 6- to approximately 11-fold ), MMP-9 ( from approximately 3- to approximately 23-fold ), MT1-MMP ( from approximately 8- to approximately 20-fold ), MMP-2 gelatinolytic activity ( from 2- to 3-fold ), and JNK and p38 mitogen activated protein kinase ( MAPK ) activities but decreased insulin mediated activation of PI3K and ERK1/2
San José et al., Free Radic Biol Med 2009 : Insulin mediated NADPH oxidase activation stimulated MMP-9 activation in monocytes and cell proliferation in macrophages
Guo et al., J Vasc Res 2013 (Carotid Artery Injuries...) : Insulin also reduced mRNA levels of MMP-2 ( p < 0.05 ) and MMP-9 ( p < 0.05 ) and protein levels of MMP-2 ( p < 0.05 )