Gene interactions and pathways from curated databases and text-mining

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INS — MCOLN1

Text-mined interactions from Literome

King et al., Am J Physiol 1976 : Chicken insulin secretory responses to glucose, glucagon, tolbutamide, and lack of Mg2+ were measured using isolated perfused in situ chicken pancreata
Murakami et al., Proc Soc Exp Biol Med 1992 (Insulinoma...) : An absence of Mg2+ in the extracellular space may result in enhanced insulin secretion
Hwang et al., Biochim Biophys Acta 1991 : Mg2+ inhibits the specific [ 3H ] Ins ( 1,4,5 ) P3 binding
Nagy et al., Endocrinology 1990 (Insulin Resistance) : The effects of insulin receptor antibodies on basal and insulin stimulated ( Ca2+ + Mg2+ ) ATPase activities were specific
Levy et al., Diabetes 1986 (Diabetes Mellitus, Experimental...) : The direct effect of insulin on the high-affinity Ca2+-Mg2+-ATPase was studied in kidney proximal tubular basolateral membranes (BLM) obtained from control and streptozocin induced non-insulin dependent diabetes mellitus ( NIDDM ) rats ... Insulin ( 16-200 microU/ml ) significantly increased the high-affinity Ca2+-Mg2+-ATPase activity ( 17-40 % ) in membranes from control animals but had no effect on the enzyme activity in the membranes from the NIDDM rats
Agarwal et al., Acta Diabetol Lat 1985 (Diabetes Mellitus, Experimental) : The in vitro effect of porcine insulin on Na+ + K+, Ca2+- and Mg2+-ATPases of the rat erythrocyte membrane of normal and alloxan induced diabetic rats was investigated
Levy et al., Endocrinology 1986 : At 0.1 microM free Ca2+, insulin ( 25-100 microU/ml ) increased ( Ca2+ + Mg2+ ) ATPase activity in a dose dependent manner by 35-52 % ( P less than 0.01 ) and by 8-13 % ( P less than 0.05 to P less than 0.01 ) at a 3-microM free Ca2+ concentration ; hPTH- ( 1-34 ) PTH ( 10 ( -9 ) -10 ( -7 ) M ) increased the enzyme activity at a free Ca2+ concentration of 0.1 microM by 13-25 % ( P less than 0.05 to P less than 0.01 )
Inoue et al., Brain Res 1995 : The AlF INS in the presence of 12 microM Mg2+ reversed polarity at about +9 mV, irrespective of the extent of decline
Malaisse et al., Diabete Metab 1976 : Mg2+ in high concentration ( 10 to 20 mEq/l ) caused a dose related inhibition of glucose induced 45calcium net uptake and subsequent insulin release in isolated islets
Van Delden et al., J Biol Chem 1993 (Leukemia, Promyelocytic, Acute) : The effects of Ca2+ and Mg2+ on Ins ( 1,4,5 ) P3 binding were conserved after solubilization of HL-60 membranes ... Mg2+ acts either directly on the Ins ( 1,4,5 ) P3 receptor or on a closely associated target