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IGFBP2 — INS

Text-mined interactions from Literome

Demori et al., J Endocrinol 1999 (Hypothyroidism) : The latter result confirmed the dominant role of insulin in regulating IGFBP-2 expression by cultured hepatocytes
Hodgson et al., Regul Pept 2000 : Insulin-like growth factor binding proteins ( IGFBP ) can inhibit or accentuate the mitogenic activities of insulin-like growth factor 1 (IGF-1) depending upon the experimental model employed
Dahlfors et al., Endocrinology 2000 : IGF-I, insulin , or angiotensin II did not affect IGF-I or IGFBP mRNA expression
Chamberlain et al., Mol Cell Endocrinol 2001 : Production of IGFBP-2/-5 by granulosa cells in Experiment 2B was inhibited by insulin , with EGF and bFGF further enhancing insulin 's inhibitory effect ; follicle stimulating hormone was without effect
Greisen et al., Fertil Steril 2002 (Polycystic Ovary Syndrome) : The release of IGFBP-2 and IGFBP-4 was significantly stimulated by insulin , whereas LH had no effect
Sandhu et al., J Natl Cancer Inst 2002 (Colorectal Neoplasms) : IGF-I bioactivity is regulated in part by its six binding proteins ( IGFBP-1 to IGFBP-6 ) ; insulin inhibits the production of IGFBP-1 and perhaps IGFBP-2
Mesotten et al., J Clin Endocrinol Metab 2002 (Chronic Disease...) : In the liver, IGFBP-1 is transcriptionally repressed by insulin , and it is therefore a potential marker of hepatic insulin sensitivity
Hsu et al., J Biol Chem 1992 : Unlike cell associated IGFBP-30K, secretion of IGFBP was stimulated ( 6.8 +/- 0.5-fold, n = 2 ) by IGF-I, whereas IGFBP secretion was inhibited 54 % by insulin
Schmid et al., FEBS Lett 1992 : Retinoic acid and insulin regulate IGFBP-2 expression in a tissue-specific manner
Grimes et al., Endocrinology 1992 : IGF-I, IGF-II, and the IGF-I analogs, but not insulin , also induced production of an unidentified 30-kDa IGFBP not normally detectable in these cultures ... However, in the presence of epidermal growth factor ( which was without independent effect on the 30-kDa IGFBP ), insulin also induced this 30-kDa IGFBP ... In summary, insulin stimulated IGFBP-3 and -2 production in a manner that mimics that of IGF-I and the more potent long R3-IGF-I
Giudice et al., J Clin Endocrinol Metab 1992 : Since insulin-like growth factors (IGFs) and IGF binding proteins ( IGFBPs ) are believed to be involved in endometrial differentiation, and insulin regulates IGFBP production in a variety of cells, we have investigated the modulatory roles of EGF, progesterone, and insulin on IGFBP secretion by long term cultures of human endometrial stromal cells ... In the nondecidualized state, insulin increased the secretion of IGFBP-3, IGFBP-2 , and the 24-kDa IGFBP, which were slightly inhibited by EGF and relatively unaffected by progesterone alone
Hwang et al., Growth Horm IGF Res 2003 (Carcinoma, Hepatocellular...) : In normal physiology, IGFBP-1 transcription is potently inhibited by insulin and serum levels are limited by a rapid clearance rate
Voge et al., Domest Anim Endocrinol 2004 : These results indicate that expression of IGFBP-2 , -3, -4, and -5 mRNA by granulosa and theca cells are differentially regulated by estradiol, insulin and gonadotropins, therefore discretely modulating the amount of bioavailable IGFs to these cells depending upon the specific hormonal stimuli
Thraikill et al., J Clin Invest 1990 : Cultured human decidual cells release three IGF-BPs with 24,000, 30,000, and 34,000 Mr. Using ligand blot analysis and an RIA for the 30,000-Mr form ( IGF-BP-1 ), we examined the effects of IGF-I ( 10-1,000 ng/ml ), insulin ( 10-10,000 ng/ml ), and relaxin ( 10-250 ng/ml ) on decidual cell IGF-BP release after 120 h of hormone exposure
McGrath et al., Endocrinology 1991 : Using RIA analysis, bovine mammary cells cultured in the presence of IGF-1 produced 20-25 ng/ml IGFBP-2 compared to control cultures which secrete approximately 1.0 ng/ml. Cells exposed to des-3-IGF-1 produced 40-60 % less IGFBP-2 whereas insulin and IGF-2 did not stimulate significant IGFBP-2 production
Clemmons et al., J Clin Endocrinol Metab 1991 (Acromegaly...) : Acute stimulation of insulin secretion does not suppress IGFBP-2 , and there is much less daily fluctuation compared to IGFBP-1
Zhang et al., Biochem Biophys Res Commun 2007 (Diabetes Mellitus, Type 2) : In contrast, IGFBP-1 augmented glucose stimulated insulin secretion in intact islets, associated with a reduced somatostatin secretion
Fleming et al., Reproductive biology and endocrinology : RB&E 2008 : The purpose of this study was to examine the effect of insulin on expression and synthesis of IGFBP-1 and IGFBP-2 in the baboon endometrium in vitro ... Insulin clearly inhibited IGFBP-1 production and mRNA expression in a time- and dose dependent manner, whereas IGFBP-2 synthesis was not significantly affected ... Insulin differentially regulates endometrial IGFBP-1 and IGFBP-2 secretion in the baboon
Martin et al., Endocrinology 1990 (Cell Transformation, Neoplastic) : Insulin tested at 1 microgram/ml did not induce 29-31 K IGFBP
Li et al., Mol Cell Endocrinol 2012 : Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway ... These findings suggest that insulin upregulates IGFBP-2 expression through a PI3K/mTOR/C/EBPa pathway in white adipocytes
Fang et al., Mol Biol Rep 2012 : Insulin also up-regulated the expression of GHR, IR, IGFBP3 , and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA
Pekonen et al., Fertil Steril 1989 (Obesity...) : The authors evaluated the role of insulin in the regulation of serum levels of 34K IGF-BP in patients with polycystic ovarian disease ( PCOD )
Irwin et al., Regul Pept 1993 : We have investigated the regulation by insulin , IGF-I, and IGF-II, of IGFBP secretion in human endometrial stromal cells decidualized in vitro, and examined the interrelationship between the induced changes in IGFBP levels and the biological responses of stromal cells to IGFs
Boisclair et al., Growth Regul 1994 : Insulin-like growth factor-I and insulin stimulate the synthesis of IGF binding protein-2 in a human embryonic kidney cell line ... The stimulation of IGFBP-2 by IGF-I and insulin was reversibly abolished by incubation with protein synthesis inhibitors such as cycloheximide
McFarland et al., Gen Comp Endocrinol 1993 : Equimolar levels of IGF-I or insulin stimulated IGFBP release, however, at levels lower than that induced by IGF-II
Lee et al., Proc Soc Exp Biol Med 1993 : Furthermore, IGFBP-1 regulation by insulin and glucoregulatory hormones in vitro and limited in vivo data are consistent with a role for IGFBP-1 in glucose counterregulation
Bereket et al., J Clin Endocrinol Metab 1995 (Diabetes Mellitus, Type 1...) : In vitro and animal data have identified the role of insulin in the regulation of IGFBP-2 , but such a relationship has not been established clearly in humans ... These results indicate that long standing alterations in serum insulin concentrations beyond the physiological range have significant influence on serum IGFBP-2 levels in children and confirm earlier findings that serum IGFBP-2 levels are not acutely regulated by insulin
McCusker et al., J Cell Physiol 1998 : IGFBP secretion by L6 cells is stimulated by both insulin/IGF-I and cAMP dependent pathways, whereas IGFBP-5 secretion by BC3H-1 cells is stimulated only by the insulin/IGF pathway