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HNF4A — INS

Text-mined interactions from Literome

Shih et al., Proc Natl Acad Sci U S A 2002 : In mice, a heterozygous mutation in Pdx-1 alone, but not Hnf-1alpha ( +/- ), Hnf-3beta ( +/- ), or Hnf-4alpha ( +/- ), causes impaired glucose stimulated insulin secretion in mice
Miura et al., J Biol Chem 2006 : Hepatocyte nuclear factor-4alpha is essential for glucose stimulated insulin secretion by pancreatic beta-cells
Love-Gregory et al., Curr Opin Clin Nutr Metab Care 2007 (Diabetes Mellitus, Type 2...) : These studies report newly identified variants, evaluate previously reported polymorphisms that were associated with type 2 diabetes in several distinct populations with maturity-onset diabetes of the young, type 2 diabetes, gestational diabetes, and diabetes related risk factors, and propose a role for HNF4A in insulin secretion via the potassium ATP channel
Maestro et al., Endocr Dev 2007 (Diabetes Mellitus, Type 2) : Recent studies show that Hnf4alpha deficiency in mice causes not only abnormal insulin secretion, but also an impairment of the expansion of beta-cell mass that normally occurs during pregnancy
Wang et al., Chin Med J (Engl) 2009 (Diabetes Mellitus, Type 2...) : And we also observed that ABCC8 as well as the interaction between PPARG and HNF4A may contribute to post-challenge insulin secretion