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GNRH1 — INS

Text-mined interactions from Literome

Baranowska et al., Gynecol Endocrinol 1999 (Obesity...) : No significant correlations were found between galanin, NPY and percentage change in response of LH to LHRH , as well as between NPY and insulin , and galanin and testosterone
Kovacs et al., Neuroendocrinology 2002 (Diabetes Mellitus, Experimental) : Effect of centrally administered insulin on gonadotropin releasing hormone neuron activity and luteinizing hormone surge in the diabetic female rat
Ferin et al., J Clin Endocrinol Metab 2003 : LH and 17-hydroxyprogesterone responses to GnRH agonist challenges and the insulin response to glucose tolerance tests were similar in control and VPA groups
Weiss et al., Arch Gynecol Obstet 2003 (Calcium Signaling) : Insulin did not affect GnRH- and TRH induced Ca ( 2+ ) signals compared to controls
Burcelin et al., Endocrinology 2003 : Because energy homeostasis and reproductive function are closely related phenomena, we investigated the respective roles played by insulin and leptin in the hypothalamic control of GnRH secretion ... Leptin was found to potentiate the effect of insulin on GnRH secretion in vitro but was devoid of any effect on its own
Zacharieva et al., Diabete Metab 1992 : GRH significantly reduced serum insulin in the two treatment groups ... PGE2 infusion or meclofenamate did not change insulin response to GRH
Arias et al., Neuroendocrinology 1992 : Effect of insulin on LHRH release by perifused hypothalamic fragments
Allon et al., Fertil Steril 2005 (Chronic Disease...) : Intracerebroventricular ( ICV ) insulin alone increased LH in response to GnRH
Kim et al., Mol Cell Endocrinol 2005 (MAP Kinase Signaling System) : Insulin regulation of GnRH gene expression through MAP kinase signaling pathways ... Insulin also stimulated GnRH promoter activity in GnRH neurons
Garmes et al., Gynecol Endocrinol 2005 (Hyperandrogenism...) : In the present study, we evaluated the effect of pioglitazone ( 30 mg/day for 2 months ) on insulin response to an oral glucose tolerance test ( OGTT ), serum levels of androgens and sex hormone binding globulin (SHBG), and pituitary gonadotropin response to GnRH stimulation in 15 obese PCOS women
Gamba et al., Mol Cell Endocrinol 2006 : Using primary neuronal cultures as well as a novel GnRH neuronal cell line obtained by conditional immortalization of adult rat hypothalamic neurons, we have recently demonstrated that this effect of insulin on GnRH gene expression is probably mediated directly at the level of GnRH neurons, and involves the stimulation of the MAP kinase Erk1/2 pathway
DiVall et al., Mol Cell Endocrinol 2007 : Insulin increases gonadotropin releasing hormone (GnRH) gene expression in in vitro models of GnRH neurons ... Egr-1 small interfering RNA blocks the insulin induced increase in GnRH promoter activity, measured as luciferase expression ... Mutagenesis of a putative Egr-1 binding site within the proximal region blocks the insulin induced increase in GnRH promoter activity ... Thus, Egr-1 binds the GnRH promoter at a site between -67 and -76bp from the transcriptional start site to mediate the insulin induced increase in GnRH gene transcription
Lawson et al., J Clin Endocrinol Metab 2008 (Polycystic Ovary Syndrome) : In normal women, insulin negatively correlates with mean LH and suppresses GnRH response at a high infusion rate
Navratil et al., Mol Cell Endocrinol 2009 : Insulin augments gonadotropin releasing hormone induction of translation in LbetaT2 cells
Würzburger et al., Clin Endocrinol (Oxf) 1990 (Diabetes Mellitus, Type 1...) : Effects of improved blood glucose on insulin induced hypoglycaemia, TRH, GnRH and exercise tests in insulin dependent diabetes
Naor et al., Biochem Biophys Res Commun 1987 : The stimulatory effect of GnRH on [ 3H ] inositol phosphates (Ins-P) production in myo- [ 2-3H ] inositol prelabeled pituitary cells was not inhibited by prior treatment of the cells with TPA ( 10 ( -9 ) -10 ( -7 ) M )
Naor et al., J Biol Chem 1986 : The effect of GnRH on inositol phosphates (Ins-P) production was dose related ( ED50 = 1-5 nM ), and was blocked by a potent antagonist [ D-pGlu, pClPhe, D-Trp ] GnRH ... The effect of GnRH on [ 3H ] Ins-P accumulation was not affected by prior treatment of the cells with the tumor promoter phorbol ester 12-O-tetradecanoylphorbol-13-acetate or with islet activating protein pertussis toxin
Schneider et al., Klin Wochenschr 1978 (Acromegaly...) : The combined insulin induced hypoglycemia/LH-RH/TRH-test is therefore advisable for patients with acromegaly, since GH release as well as other hypophyseal partial functions can be tested
McArdle et al., Endocrinology 1995 : Accordingly, the data reveal a novel mechanism for homologous desensitization to GnRH in which agonist occupied GnRH receptors are rendered unable to mobilize intracellular Ca2+ and imply that desensitization of GnRH stimulated Ins ( 1,4,5 ) P3 production and/or action occurs
Judd et al., Aust N Z J Med 1976 (Acromegaly...) : Individually, insulin induced hypoglycaemia, thyrotrophin releasing hormone (TRH) and gonadotrophin releasing hormone (GnRH) have proved to be reliable stimuli for the release of the various pituary hormones
Chen et al., Endocrinology 1996 (Hypoglycemia) : The insulin hypoglycemia induced inhibition of gonadotropin releasing hormone pulse generator activity in the rhesus monkey : roles of vasopressin and corticotropin releasing factor
Tropeano et al., J Endocrinol Invest 1996 (Body Weight...) : The basal plasma levels of gonadotropins, estrogens, androgens and sex hormone binding globulin, the gonadotropin responses to gonadotropin releasing hormone (GnRH) and the insulin and C-peptide responses to a 3-hour oral glucose tolerance test ( OGTT ) were measured in 19 obese and 19 normal weight patients with PCOS and 7 obese and 8 normal weight ovulatory controls
Ehrmann et al., J Clin Endocrinol Metab 1997 (Insulin Resistance...) : Before and after treatment with troglitazone ( 400 mg daily for 12 weeks ), all had 1 ) a GnRH agonist ( leuprolide ) test, 2 ) a 75-g oral glucose tolerance test, 3 ) a frequently sampled iv glucose tolerance test to determine the insulin sensitivity index and the acute insulin response to glucose, 4 ) an oscillatory glucose infusion to assess the ability of the beta-cell to entrain to glucose as quantitated by the normalized spectral power for the insulin secretion rate, and 5 ) measures of fibrinolytic capacity [ plasminogen activator inhibitor type 1 ( PAI-1 ) and tissue plasminogen activator ]