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GHRH — INS

Text-mined interactions from Literome

Ciampelli et al., J Clin Endocrinol Metab 2001 (Insulin Resistance...) : To evaluate the effects of acute lowering of FFAs on glucose induced insulin secretion and GH response to GHRH in polycystic ovary syndrome ( PCOS ), 27 PCOS subjects ( 11 lean and 16 obese ) and 17 body mass index matched controls ( 8 lean and 9 obese ) were investigated
Hanew et al., Eur J Endocrinol 2002 : The role of endogenous GHRH in arginine-, insulin- , clonidine- and l-dopa induced GH secretion was studied in man using a GHRH antagonist (GHRH-Ant)
Aimaretti et al., J Pediatr Endocrinol 2001 (Disease Progression) : Insulin induced hypoglycemia ( ITT ) and GHRH + arginine are the tests of choice provided that appropriate cutoff limits are assumed ; these tests show good specificity and sensitivity
Aimaretti et al., Clin Endocrinol (Oxf) 2002 : In all patients, the GH response to insulin induced hypoglycaemia ( ITT, 0.1 IU regular insulin i.v. ) and GH releasing hormone (GHRH) ( 1 microg/kg i.v. ) + arginine ( ARG, 0.5 g/kg i.v. ) was also studied
Aimaretti et al., Clin Endocrinol (Oxf) 2003 (Hypopituitarism) : Insulin induced hypoglycaemia ( ITT ) and GH-releasing hormone (GHRH) + arginine ( ARG ) are indicated as the tests of choice, provided that appropriate cut-off limits are defined
Trainer et al., J Endocrinol 1992 : The GH response to insulin induced hypoglycaemia and growth hormone releasing hormone (GHRH) has been shown to be impaired in subjects with Cushing 's syndrome and in healthy volunteers given oral glucocorticoids
Arslanian et al., Acta Endocrinol (Copenh) 1992 (Hypopituitarism) : Effects of growth hormone releasing hormone on insulin action and insulin secretion in a hypopituitary patient evaluated by the clamp technique
Katoh et al., J Endocrinol 2004 : Changes in plasma concentrations of GH and insulin in response to feeding and stimulation with GH-releasing hormone (GHRH) or GH-releasing peptide ( GHRP-6, a ligand for endogenous GH secretagogue receptors ) were compared between 3-week-old ( milk fed ) and 12-week-old ( concentrate and hay fed ) calves
Luque et al., J Mol Endocrinol 2006 : Therefore, this study examined the effects of glucocorticoids ( dexamethasone ( 0.1-100 nM ) and hydrocortisone ( 10 nM ) ), FFA ( oleic and linoleic acid, 100 and 400 microM each ), IGF-I ( 0.5-50 nM ), and insulin ( 0.5-50 nM ) on GH release and GH, GHRH-receptor (GHRH-R) and ghrelin-receptor ( GHS-R ) mRNA levels, in primary pituitary cell cultures of baboons ( Papio anubis ) after 24 h treatment
Scacchi et al., Clin Endocrinol (Oxf) 1991 (Growth Disorders...) : Eight prepubertal patients with beta-thalassaemia major, presenting with severe growth retardation and impaired growth hormone secretion in response to provocative stimuli ( insulin induced hypoglycaemia, L-dopa and growth hormone releasing hormone ), were investigated
Foot et al., Clin Endocrinol (Oxf) 1990 (Diabetes Mellitus, Type 1) : These results indicate that glucose and insulin may play a role in the regulation of GHRH release following a mixed meal but circulating levels of GHRH and SMS are unlikely to be relevant to the abnormal regulation of GH in IDDM
Kawagishi et al., Nihon Naibunpi Gakkai Zasshi 1990 (Diabetes Mellitus, Experimental) : [ The effect of growth hormone releasing factor (GRF) on secretion of insulin , glucagon and somatostatin from perfused rat pancreas ]
de Boer et al., Clin Endocrinol (Oxf) 1989 (Acromegaly...) : GH reserve was assessed after insulin induced hypoglycaemia and GHRH ( 1-44 ) with and without pyridostigmine
Rosskamp et al., Klin Wochenschr 1988 (Diabetes Mellitus, Type 1...) : These results indicate that circulating growth hormone releasing hormone does not play a dominant role in the regulation of insulin and somatostatin
Davis et al., Pancreas 1988 (Adenoma, Islet Cell...) : Although a growth hormone response to insulin induced hypoglycemia and supramaximal GHRH was absent, the patient 's thyroid stimulating hormone response to TRH was normal
Ghigo et al., J Clin Endocrinol Metab 1987 (Dwarfism, Pituitary) : In this study the effects of PD ( 60 mg, orally ) on both basal and GHRH ( 1 microgram/kg ) -induced GH secretion in seven children with familial short stature ( FSS ), six with GH deficiency ( GHD ) and 10 with constitutional growth delay (CGD) were studied and compared with results obtained by stimulation with insulin induced hypoglycemia ( IH ) and GHRH alone
Tapanainen et al., J Clin Endocrinol Metab 1988 : The effects of synthetic GHRH- ( 1-44 ) ( 1 microgram/kg, iv ), clonidine ( 0.15 mg/m2, orally ), L-dopa ( 0.5 g, orally ), and insulin ( 0.1 IU/kg, iv ) on plasma immunoreactive ( ir ) GHRH and GH levels were determined in normal men, aged 31-46 yr ( n = 4-8 )
Engström et al., Horm Res 1994 : Lack of evidence for acute effects of growth hormone releasing hormone on serum insulin and glucose levels in normal and hypophysectomized rats ... We also studied the acute effects of GHRH as such on insulin release in vivo and in vitro ... In isolated rat islets, cultured for 3 days at 11.1 mM glucose, 0.1-10 nM GHRH stimulated basal insulin release at 3 mM glucose ... To summarize, GHRH at high concentrations stimulates insulin release in vitro, but neither GHRH, at a concentration where GH secretion is greatly stimulated, nor GHRH induced GH release, have any acute effects on serum insulin or glucose levels
Ryan et al., J Am Acad Child Adolesc Psychiatry 1994 : GH responses to insulin induced hypoglycemia and to GHRH stimulation were blunted in depressed children compared to the normal controls
Wurzburger et al., J Clin Endocrinol Metab 1993 (Diabetes Mellitus, Type 1) : The 24-h GH and blood glucose profiles, insulin-like growth factor I (IGF-I) concentrations and GH responses to GRF were analyzed in 21 insulin dependent diabetics and 4 healthy subjects before and after 7 days treatment with recombinant human GH ( rhGH ) ( 4 IU given sc at 0800 h )
Iglesias et al., J Endocrinol Invest 1996 (Brain Injuries...) : However, GH response was reduced both to insulin induced hypoglycemia, clonidine and GHRH tests
Beentjes et al., Clin Endocrinol (Oxf) 1996 (Adenoma...) : Divergence between growth hormone responses to insulin induced hypoglycaemia and growth hormone releasing hormone in patients with non functioning pituitary macroadenomas and hyperprolactinaemia
Bellone et al., J Pediatr Endocrinol 1996 : In 43 children with normal short stature ( 5.3-14.0 yr ; 30 M and 13 F ) the effects of the infusion of phenylalanine ( Phe, 0.08 g/kg ), histidine ( His, 0.1 g/kg ), and leucine ( Leu, 0.08 g/kg ) on basal and GHRH stimulated GH secretion and on PRL, insulin and glucose levels were studied and compared with those of arginine at high ( hArg, 0.5 g/kg ) or low dose ( lArg, 0.2 g/kg ) ... Though a trend toward an increase in basal GH levels was found after His, His and Leu did not significantly modify either basal or GHRH induced GH secretion nor basal PRL, insulin and glucose levels
Lanzi et al., J Clin Endocrinol Metab 1997 : Pooling the three tests together, a significant negative regression was observed between mean serum immunoreactive insulin levels and the GH response to GHRH ( r = -0.629, P < 0.01 )
Aimaretti et al., J Clin Endocrinol Metab 1998 (Hypoglycemia...) : Comparison between insulin induced hypoglycemia and growth hormone (GH) releasing hormone + arginine as provocative tests for the diagnosis of GH deficiency in adults