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GHR — INS

Text-mined interactions from Literome

Rhoads et al., J Nutr 2004 : Insulin increases the abundance of the growth hormone receptor in liver and adipose tissue of periparturient dairy cows
Guo et al., Endocrinology 2005 (Glucose Intolerance) : GH receptor gene deficiency ( GHR ( -/- ) ) caused diminished pancreatic islet cell mass and serum insulin level and elevated insulin sensitivity
Robertson et al., Am J Physiol Endocrinol Metab 2006 (Body Weight...) : Growth hormone receptor gene deficiency causes delayed insulin responsiveness in skeletal muscles without affecting compensatory islet cell overgrowth in obese mice
Lim et al., Horm Metab Res 1990 : Our results also imply that the type 1 GH receptor of Barnard, Bundesen, Rylatt and Waters ( 1985 ) does not mediate the insulin like actions of GH on rat diaphragm
Gormsen et al., Clin Endocrinol (Oxf) 2007 : Neither GH administration nor GHR blockade resulted in significant alterations in total ghrelin levels in the presence of unaltered insulin and FFA levels
Bennett et al., Mol Cell Endocrinol 2007 (Carcinoma, Hepatocellular...) : Insulin regulation of growth hormone receptor gene expression ... The present study used rat hepatoma cells to examine the effects of insulin and GH on GHR gene expression ... This effect of insulin occurred at physiologic concentrations, occurred many hours before the insulin regulated decrease in GHR protein, and was mediated by reduction of GHR transcription
Bennett et al., Endocrine 2007 (Carcinoma, Hepatocellular...) : Insulin regulation of growth hormone receptor gene expression : involvement of both the PI-3 kinase and MEK/ERK signaling pathways ... Collectively, these data suggest that insulin signaling via either the PI-3 kinase or MEK/ERK pathway may result in partial reduction of GHR gene expression, whereas signaling via both pathways may be required to achieve the full insulin effect
Schneider et al., Animal 2011 : Effect of exogenous insulin and fasting on growth hormone receptor and IGF-I expression in the pre-ovulatory follicle of ewes
Pierce et al., Gen Comp Endocrinol 2012 : We investigated the effects of GH, insulin , glucagon, cortisol and triiodothyronine on GHR1 and GHR2 mRNA levels in primary cultured tilapia hepatocytes ... Insulin suppressed stimulation of GHR2 mRNA level by GH ( 10 ( -8 ) -10 ( -6 ) M ) ... Insulin increased basal GHR1 mRNA level ( 10 ( -8 ) -10 ( -6 ) M ) ... This study shows that GHR1 and GHR2 gene expression are differentially regulated by physiological levels of GH and insulin in tilapia primary hepatocytes
Fang et al., Mol Biol Rep 2012 : Insulin also up-regulated the expression of GHR , IR, IGFBP3, and IGFBP4 mRNAs, and tended to prevent the transcript levels of IGF-I and IGFBP4 improved by ALA
Chipkin et al., Endocrinology 1989 : Different growth hormone-receptor interactions mediate insulin-like and lipolytic responses of rat adipose tissue
Chen et al., Endocrinology 1997 (Diabetes Mellitus, Experimental) : The lowered GHR binding in diabetic NTg and GHA-Tg mice suggests the involvement of insulin in the regulation of GHR expression