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GAPDH — INS

Text-mined interactions from Literome

de la Monte et al., Alcohol Clin Exp Res 1999 : This study explores the roles of the Grb2- and Syp binding motifs of IRS-1 in relation to the inhibitory effects of ethanol on insulin stimulated DNA synthesis, proliferating cell nuclear antigen ( PCNA ) and glyceraldehyde 3-phosphate dehydrogenase ( GAPDH ) expression, and activation of mitogen activated protein kinase ( MAPK ), which is known to be essential for cell proliferation ... Ethanol exposure decreased insulin stimulated DNA synthesis, PCNA, GAPDH , and activated MAPK levels in all clones, but the wild-type IRS-1 transfectants were relatively resistant, and the IRS-1deltaGrb2 transfectants were extraordinarily sensitive to these inhibitory effects of ethanol
Barroso et al., Eur J Endocrinol 1999 : Co-operation was elucidated between norepinephrine- and insulin mediated induction of GAPDH mRNA levels
Crandall et al., Biochem Biophys Res Commun 2000 : The cultures did exhibit insulin stimulated glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ) expression and leptin synthesis following differentiation to the adipocyte phenotype
Alexander-Bridges et al., J Cell Biochem 1992 : Insulin induces glyceraldehyde-3-phosphate dehydrogenase ( GADPH ) gene transcription in part by regulating one or more proteins that bind a cis acting element, IRE-A ... Insulin regulates GAPDH gene transcription in a tissue-specific manner
Alexander-Bridges et al., Mol Cell Biochem 1992 (Diabetes Mellitus, Experimental) : In ongoing studies aimed at elucidating the mechanism of insulin action on the expression of genes that modulate glucose utilization and cell growth, we have focused on the inductive effect of insulin on transcription of glyceraldehyde-3-phosphate dehydrogenase ( GAPDH ) and the early growth response gene, Egr-1 ... We present evidence that supports the role of protein phosphorylation in mediating the effect of insulin on activation of Egr-1 and GAPDH gene transcription
Min et al., Nat Chem Biol 2007 : Forward chemical genetic approach identifies new role for GAPDH in insulin signaling
Alexander et al., Proc Natl Acad Sci U S A 1988 (Carcinoma, Hepatocellular...) : Insulin stimulates glyceraldehyde-3-phosphate dehydrogenase gene expression through cis acting DNA sequences ... To examine the mechanism by which insulin regulates GAPDH mRNA levels in these two insulin-sensitive tissues, we have isolated a functional human GAPDH gene ... When stably transfected and expressed in 3T3-F442A preadipocytes and H35 hepatoma cells, the intact human GAPDH gene is induced 10-fold by insulin in 3T3-F442A adipocytes and 3-fold by insulin in H35 hepatoma lines, which is similar to the induction obtained with the endogenous gene ... Thus, the inductive effect of insulin on human GAPDH gene expression is mediated through cis acting sequences located between -487 and +20 of the human GAPDH gene
Rolland et al., J Biol Chem 1995 (Obesity) : Using this system we found a direct effect of insulin on GAPDH and FAS gene expression in rat adipocytes