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CPE — INS
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Polastri et al., Cell Transplant 2002
:
Effects of
carboxypeptidase E overexpression on insulin mRNA levels,
regulated insulin secretion, and proinsulin processing of pituitary GH3 cells transfected with a furin-cleavable human proinsulin cDNA ... In conclusion,
Cpe overexpression can
increase regulated
insulin secretion and proinsulin processing in InsGH3 cells ; however, such improvements appear quantitatively and qualitatively modest
Hawkins et al., Toxicological sciences : an official journal of the Society of Toxicology 2004
:
These alterations in PPImRNA distribution were found to be concentration dependent, chemical structure-specific, and reversible with a time course consistent with a previously reported
CPH induced inhibition of
insulin synthesis
Miller et al., Endocrinology 1991
:
These studies examined the mechanism of CPH induced insulin depletion by determining the time course for
CPH induced changes in pancreatic preproinsulin mRNA, proinsulin, and
insulin levels
Miller et al., Biochem Pharmacol 1990
:
Cyproheptadine (CPH) inhibits glucose stimulated
insulin synthesis and secretion, and reversibly depletes pancreatic insulin content in the rat
Min et al., Int J Obes Relat Metab Disord 2013
(Obesity) :
We then examined whether
CPE regulates
insulin receptor (IR) , a common upstream regulator of ERK and Akt
Chow et al., Cell Biol Toxicol 1989
:
The biosynthesis of ( pro )
insulin was also
inhibited by
CPH and DMCPH-epoxide in islets isolated from 21-day-old rat fetuses
Klöppel et al., Acta Endocrinol (Copenh) 1978
:
The results suggest that
CPH and MH
inhibit insulin release by either directly or indirectly interfering with the normal calcium handling by the B cell
Halban et al., Endocrinology 1979
:
CPH added over 6 days
resulted in either an increase ( 5 X 10 ( -7 ) M CPH ) or a marked, but reversible decrease ( 5 X 10 ( -5 M ) in
insulin content of islets when related to that of controls
Pezzarossa et al., Acta Diabetol Lat 1982
:
These data are in agreement with the hypothesis that in vivo
CPH action on
insulin secretion may be partly mediated by its effects on circulating glucagon levels
Miller et al., J Biochem Toxicol 1993
(Insulinoma...) :
This suggests that an effect on transcription may not be the primary action by which
CPH and its analogs
inhibit insulin synthesis in vivo