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IL6ST — SOCS3

Pathways - manually collected, often from reviews:

• KEGG Jak-STAT signaling pathway: SOCS1/SOCS2/SOCS3/SOCS4/SOCS5/SOCS7 → CNTFR/CRLF2/CSF2RA/CSF2RB/CSF3R/EPOR/GHR/IFNAR1/IFNAR2/IFNGR1/IFNGR2/IFNLR1/IL10RA/IL10RB/IL11RA/IL12RB1/IL12RB2/IL13RA1/IL13RA2/IL15RA/IL20RA/IL20RB/IL21R/IL22RA1/IL22RA2/IL23R/IL2RA/IL2RB/IL2RG/IL3RA/IL4R/IL5RA/IL6R/IL6ST/IL7R/IL9R/LEPR/LIFR/MPL/OSMR/PRLR (protein-protein, inhibition)
  
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, activates)
  Lang et al., Nat Immunol 2003, Schaper et al., Biochem J 1998
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → SOCS3 (SOCS3) (modification, collaborate) Schmitz et al., J Biol Chem 2000
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, collaborate)
  Schmitz et al., J Biol Chem 2000
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: SOCS3 (SOCS3) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, collaborate)
  Schmitz et al., J Biol Chem 2000
  Evidence: physical interaction
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, activates)
  Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Gerhartz et al., J Biol Chem 1996
  Evidence: mutant phenotype, other species
• NCI Pathway Database IL6-mediated signaling events: IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4 complex (IL6-IL6R-IL6ST-JAK1-LMO4) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, activates)
  Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• NCI Pathway Database IL6-mediated signaling events: nPKC-delta (PRKCD) → IL6/IL6RA/gp130 (dimer)/JAK1/JAK1/LMO4/SOCS3 complex (IL6-IL6R-IL6ST-JAK1-LMO4-SOCS3) (modification, activates)
  Jain et al., J Biol Chem 1999, Schuringa et al., J Biol Chem 2001, Novotny-Diermayr et al., J Biol Chem 2002, Croker et al., Nat Immunol 2003, Lang et al., Nat Immunol 2003, Yasukawa et al., Nat Immunol 2003, Novotny-Diermayr et al., J Biol Chem 2005, Guschin et al., EMBO J 1995, Wegenka et al., Mol Cell Biol 1993, Zhong et al., Science 1994, Wegenka et al., Mol Cell Biol 1994, Lütticken et al., Science 1994, Kaptein et al., J Biol Chem 1996, Gerhartz et al., J Biol Chem 1996, Haan et al., J Biol Chem 1999
  Evidence: mutant phenotype, assay, physical interaction, other species
• Reactome Reaction: SOCS3 → IL6ST (indirect_complex) Schmitz et al., J Biol Chem 2000
• Reactome Reaction: SOCS3 → IL6ST (reaction) Schmitz et al., J Biol Chem 2000

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SOCS3 — IL6ST (physical association, affinity chromatography technology) Lehmann et al., J Biol Chem 2003*
• IRef Biogrid Interaction: SOCS3 — IL6ST (direct interaction, pull down) Schmitz et al., J Biol Chem 2000
• IRef Biogrid Interaction: SOCS3 — IL6ST (direct interaction, pull down) Lehmann et al., J Biol Chem 2003*
• MIPS CORUM LMO4-gp130 complex: LMO4-gp130 complex complex (IL6ST-JAK1-LMO4-PTPN11-SOCS3) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Corum Interaction: Complex of SOCS3-JAK1-IL6ST-LMO4-PTPN11 (association, anti tag coimmunoprecipitation) Novotny-Diermayr et al., J Biol Chem 2005
• IRef Hprd Interaction: SOCS3 — IL6ST (in vivo) Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*
• IRef Hprd Interaction: SOCS3 — IL6ST (in vitro) Anhuf et al., J Immunol 2000*, Lehmann et al., J Biol Chem 2003*
• IRef Ophid Interaction: IL6ST — SOCS3 (aggregation, confirmational text mining) Anhuf et al., J Immunol 2000*
• IRef Ophid Interaction: IL6ST — SOCS3 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005

Text-mined interactions from Literome

Yajima et al., Circulation 2006 (Cardiomyopathies...) : Interestingly, gp130-cytokine mediated stimulation of neonatal ventricular myocytes has a cytoprotective effect against virus infection in culture that can be inhibited by suppressors of cytokine signaling (SOCS)-3 , a physiological inhibitor of gp130 signaling that does not affect IFN signaling ... SOCS3 mediated regulation of gp130 signaling can affect susceptibility to viral infection in the heart
Dierssen et al., J Biol Chem 2008 (Acute-Phase Reaction...) : In summary, gp130 dependent STAT3 activation and concomitant SOCS3 during liver regeneration is involved in timing of DNA synthesis and protects hepatocyte proliferation during stress conditions
Ogura et al., Immunity 2008 (Arthritis...) : Importantly, enhancement of this loop caused by disruption of suppressor of cytokine signaling 3 ( SOCS3 ) -dependent negative regulation of the IL-6 signal transducer gp130 contributed to the development of arthritis
Yajima et al., Circulation 2011 (Arrhythmias, Cardiac...) : Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130 dependent manner accompanied by contractile dysfunction and ventricular arrhythmias ... Our results demonstrate an important role of SOCS3 regulation on cardiac gp130 signaling in the pathogenesis of contractile dysfunction and ventricular arrhythmias