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IL1A — TLR3
Text-mined interactions from Literome
Yamamoto et al., Nature 2004
:
Transcription of IkappaBzeta is rapidly induced by
stimulation with
TLR ligands and
interleukin-1 (IL-1)
Szczepański et al., Eur Arch Otorhinolaryngol 2006
(Cholesteatoma, Middle Ear...) :
TLR-ligand binding
results in cell signal transduction and subsequent production of various proinflammatory cytokines such as
IL-1 and TNF-alpha
van Beelen et al., Immunity 2007
(Bacterial Infections...) :
MDP enhanced obligate bacterial
Toll-like receptor ( TLR ) agonist
induction of IL-23 and
IL-1 , which promoted IL-17 expression in T cells
Croker et al., Proc Natl Acad Sci U S A 2008
(Autoimmune Diseases...) :
TLR induced TNF and
IL-1 production are normal in macrophages derived from spin mice
Böni-Schnetzler et al., Endocrinology 2009
:
We conclude that FFA and
TLR stimulation
induce proinflammatory factors in islets and that
IL-1RI engagement results in signal amplification
Dewamitta et al., Infect Immun 2010
:
The
Toll-like receptor ( TLR ) /MyD88 signaling pathway was exclusively
required for the expression of
pro-IL-1 alpha , independently of LLO mediated cytoplasmic entry of L. monocytogenes
Chávez-Sánchez et al., Lipids in health and disease 2010
:
The activation of CD14,
TLR4 , and TLR2 by mmLDL
induces IL-1ß , IL-6, and IL-10 secretion in human monocytes and macrophages
Dasu et al., Am J Physiol Endocrinol Metab 2011
(Diabetes Mellitus, Type 2...) :
Silencing TLR2,
TLR4 , and p47phox with small inhibitory RNAs ( siRNAs ) significantly
reduced superoxide release, NF-?B activity,
IL-1ß , and MCP-1 secretion in HG and palmitate treated THP-1 cells
Carta et al., J Biol Chem 2011
:
TLR engagement induces an effective redox response with
increased ROS generation followed by a sustained antioxidant response, parallelled by efficient
IL-1ß secretion
Das et al., Immunol Cell Biol 2012
(Leishmaniasis, Visceral) :
In this report, we demonstrated that later stages of L. donovani infection rendered tolerance to macrophages, leading to incapability for the production of inflammatory cytokines like tumor necrosis factor (TNF)-a and
interleukin (IL)-1ß in
response to
TLR stimulation
den Dunnen et al., Blood 2012
(Bacterial Infections...) :
First,
TLR-Fc?RIIa costimulation strongly
increased transcription of
pro-IL-1ß and IL-23p19
Villacres et al., J Infect Dis 2012
(HIV Infections...) :
Peripheral blood mononuclear cells ( PBMCs ) obtained at baseline were used to measure
interleukin 1ß (IL-1ß) , interleukin 6 (IL-6), interleukin 10 (IL-10), interleukin 12 (IL-12), and tumor necrosis factor a (TNF-a)
responses to
Toll-like receptor (TLR) 3 and TLR4 stimulation
Kavathas et al., Mucosal Immunol 2013
:
In addition, we demonstrate that Ct-induced
IL-1ß production and secretion by the trophoblast is
independent of TLR2,
TLR4 , MyD88, and the Nalp3/ASC inflammasome
Perugorria et al., Hepatology 2013
(Liver Cirrhosis...) :
KCs lacking Tpl2 display defects with
TLR induction of cytokines
interleukin (IL)-1ß , IL-10, and IL-23
Gupta et al., Cell Signal 2013
(Glioma...) :
Importantly, ß-defensin-3 prevented
IL-1ß induced HLA-G,
TLR4 , HMGB1 expression and release of pro-inflammatory mediators
He et al., J Immunol 2013
:
Furthermore, they challenge the idea that the ATP-P2X7 axis is critical for
TLR induced
IL-1ß production via the Nlrp3 inflammasome in vivo
Wu et al., PloS one 2013
:
We showed that the hADSCs expressed Toll-like Receptors (TLR) 1, TLR2,
TLR3 , TLR4, and TLR6 and that lipopolysaccharide (LPS) significantly
induced the production of pro-inflammatory cytokines ( Cyclooxygenase-2 (Cox-2),
Interleukin-1ß (IL-1ß) , Interleukin-6 (IL-6), and Interleukin-8 (IL-8) )
Waldschmidt et al., Vet Immunol Immunopathol 2013
:
TLR 3 stimulation with 1000ng/mL of Poly ( I:C ) during 1h
increased IFNß, IFNa,
Il-1ß and TNFa expression