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IL1A — SERPINE1

Text-mined interactions from Literome

Negoro et al., J Hypertens 2002 : IL-1 induced increases in PAI-1 production in EC transfected with reporter genes alone
Kasza et al., J Neurochem 2002 : We conclude that OSM and IL-1 regulate the PAI-1 gene expression via up-regulating c-fos levels and subsequent binding of c-fos/c-jun heterodimers to the proximal element of the PAI-1 gene
Kassis et al., Blood 1992 : Enzyme linked immunosorbent assay and immunoneutralization experiments indicate that tumor necrosis factor-alpha (TNF alpha) and interleukin-1 alpha (IL-1 alpha) do not contribute to the postoperative plasma effect on HUVEC PAI-1 synthesis
Fujisaki et al., Life Sci 2006 : In this study, we examined the effect of IL-1alpha on the expression of the MMPs, TIMPs, tPA, uPA, and PAI-1 genes in osteoblasts derived from the rat osteosarcoma cell line ROS 17/2.8 ... In contrast, PAI-1 expression decreased in the presence of IL-1alpha through day 14
Roncal et al., Journal of thrombosis and haemostasis : JTH 2006 (Atherosclerosis) : We examined the influence of the 4G/5G polymorphism in the promoter region on IL-1alpha induced PAI-1 expression by human umbilical vein endothelial cells ( HUVEC ) in presence or absence of pravastatin ... IL-1alpha increased PAI-1 secretion in a genotype dependent manner, and higher values were observed for 4G/4G compared with both 4G/5G and 5G/5G cultures ( P < 0.05 ) ... Preincubation of HUVEC with 10 microm pravastatin significantly reduced IL-1 induced PAI-1 expression in 4G/4G HUVEC compared with untreated cultures ( 177.5 % +/- 24.5 % vs. 257.9 % +/- 39.0 %, P < 0.05 ) ... The endothelial 4G/5G PAI-1 genotype influences the PAI-1 response to IL-1alpha and the modulatory effect of pravastatin
de Boer et al., Thromb Haemost 1991 : Recombinant IL-1 and rTNF each increased PAI-1 synthesis by HepG2 cells two to three fold, whereas rIL-6 hardly had an effect
Hsieh et al., J Rheumatol 2007 (Osteoarthritis, Knee) : Our findings were : ( 1 ) latent and active forms of MMP-9 secretion in synovial and some meniscal cultures were inhibited significantly by U0126, SB203580, and LY294002 ; ( 2 ) latent and active forms of MMP-2 secretion were also inhibited significantly by U0126 and LY294002, but not by SB203580, except for active MMP-2 in synovial cultures ; ( 3 ) a similar observation was seen in IL-1alpha- and LPS treated cultures ; and ( 4 ) U0126, SB203580, and LY294002 significantly decreased u-PA and PAI-1 levels in all cultures in the presence or absence of IL-1alpha and LPS
Bryan et al., Mol Cancer Res 2008 (Brain Neoplasms...) : Although IL-1 enhanced the expression of sphingosine kinase 1 (SphK1), the enzyme that produces S1P, down-regulation of SphK1 had no effect on the IL-1 induced uPAR or PAI-1 mRNA expression, suggesting that these actions of IL-1 are independent of S1P production
Zhu et al., Osteoarthritis Cartilage 2009 : Additionally, IL-1beta stimulated both HIF-1alpha and PAI-1 in articular chondrocytes, and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing
Robson et al., J Clin Lab Immunol 1990 (Acute-Phase Reaction) : We have examined the effect of purified PAI from a hepatoma cell line Hep G2, on IL-1 release from Mo with secondary effects on lymphocyte proliferation in vitro ... Partially purified PAI-1 added to human Mo cultured on 125I fibrin layer both in the presence and absence of plasminogen inhibited secretion of IL-1 by Mo in response to LPS
Campbell et al., Biochem Biophys Res Commun 1991 : To our knowledge, this is the first report where IL-1 has been found to inhibit PAI-1 expression
Iwamoto et al., Kidney Int 1990 : IL-1 enhanced the release of t-PA and PAI-1 , and TNF did that of u-PA and t-PA, while gamma-IFN showed no significant effects
Faber et al., Nutrition & diabetes 2012 : IL-6 enhanced fibrinogen synthesis 4.3-fold ( P < 0.01 ), whereas IL-1ß induced PAI-1 production 5.0-fold ( P < 0.01 ) ... IL-6 and IL-1ß produced by ( pre ) adipocytes were the strongest inducers of fibrinogen and PAI-1 secretion, respectively
Hakelius et al., Anticancer Res 2013 (Carcinoma, Squamous Cell...) : Interleukin 1 alpha ( IL1a ) up-regulated both MMP1 and MMP3 and down-regulated PAI-1 , TIMP2 and -3
de Bart et al., J Bone Miner Res 1995 (Osteosarcoma) : u-PA production was rapidly increased in MG63 by IL-1 alpha ( 10 ng/ml ), whereas an effect on t-PA production was only found after a prolonged incubation and hardly any effect of IL-1 alpha on PAI-1 production was observed
Hurwitz et al., J Clin Endocrinol Metab 1995 : The inhibitory capacity was attributable to an IL-1 mediated increase in PA inhibitor type-1 (PAI-1) production, inasmuch as urokinase inhibition could be abolished by the administration of a polyclonal antihuman PAI-1 immunoglobulin G. IL-1 treatment had no effect on plasmin or trypsin inhibition
Emeis et al., Blood 1995 : Thus, the data suggest that, in rats in vivo, TNF-alpha and IL-1 are not significantly involved in the induction of PAI-1 by endotoxin
Spencer-Green et al., Clin Immunol Immunopathol 1994 : With respect to plasminogen activator inhibitor capacity, both IL-1 and retinoic acid stimulated EC PAI-1 synthesis, but the individual effects were additive, with RA augmenting the known IL-1 effects on EC PAI-1 production
Healy et al., J Biol Chem 1994 (Acute-Phase Reaction...) : Using nuclear run-on experiments, we determined that the mechanism by which IL-1 alone, or in combination with IL-6, induced PAI-1 mRNA accumulation was to cause a 10-15-fold, transient stimulation of PAI-1 gene transcription
Robson et al., Br J Haematol 1994 : Although DD increased cell associated IL-1 beta antigen levels from median values of 188 to 1600 pg/106 cells and IL-6 antigen from 660 to 2215 pg/106 cells ( P < 0.05 ), cell associated IL-1 functional activity decreased from control levels of 98 inhibitor units/ml to 65 units/ml for cells exposed to DD. Secreted plasminogen activator inhibitor (PAI) bioactivity and PAI type 2 antigen levels were significantly increased following exposure of monocytes to DD
Zoellner et al., Thromb Haemost 1993 : IL-1 alpha and TNF alpha increased the synthesis of PAI-2 and PAI-1 by EC in a dose dependent manner
Wilson et al., Kidney Int 1996 : We investigated the effects of IL-1 on the production of tissue-type plasminogen activator ( t-PA ), urokinase ( u-PA ) and PAI-1 by glomerular cells
Seki et al., J Cell Physiol 1996 (Acute-Phase Reaction) : The IL-1 induction of PAI-1 was inhibited by actinomycin D, but not by cycloheximide ... Nuclear run-on studies demonstrated that IL-1 induced a rapid and transient increase in PAI-1 gene transcription that was maximal at 30 min. IL-1 did not stabilize PAI-1 mRNA, and might, in fact, accelerate its rate of decay
Hurwitz et al., J Soc Gynecol Investig 1995 : The IL-1 mediated effects on PA/PAI-1 were accompanied by a sevenfold increase in PGE content of the spent culture medium